Record Details

<strong>Antidiabetic and antioxidant potential of <em>Durio zibethinus</em> Murr. leaves ethanolic extract</strong>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <strong>Antidiabetic and antioxidant potential of <em>Durio zibethinus</em> Murr. leaves ethanolic extract</strong>
 
Added Entry - Uncontrolled Name Chigurupati, Sridevi
 
Uncontrolled Index Term α-Amylase, Durian, α-Glucosidase, Polyphenols, Streptozotocin
 
Summary, etc. <p style="text-align: justify;"><em>Durio zibethinus</em> Murr., commonly called Durian, though well known for its rich medicinal uses, only fewer studies are available on the leaves of this plant. In this study, we investigated the antioxidant and antidiabetic potential of ethanol extract of <em>D. zibethinus</em> leaves (DZL) from Malaysian geographical origin. DZL was subjected to the preliminary phytochemical screening along with the quantitative analysis of phenols and flavonoids. The <em>in vitro</em> antioxidant properties were evaluated by DPPH and ABTS methods and <em>in vitro</em> antidiabetic properties were evaluated by α-amylase and α-glucosidase enzyme inhibition studies. The results of the above biological activities were expressed as inhibitory concentration 50% for DZL and standard drugs (acarbose and ascorbic acid). Based on the acute oral toxicity test, two test doses (100 and 200 mg/kg) of DZL were compared with glibenclamide (5 mg/kg) for their effect on fasting blood glucose at various time intervals (0 to12 h) in glucose-loaded normoglycemic rats. DZL (200 mg/kg) showed a better response in streptozotocin (STZ) induced diabetic rats. The antioxidant assay of DZL showed an appreciable extract inhibitory concentration 50% against the free radicals generated by DPPH (1.61±0.07 μg/ mL) and ABTS (1.47±0.07 μg/mL) assays. Similarly, the <em>in vitro</em> antidiabetic assay results demonstrated a dose-dependent inhibition of α-amylase (2.58±0.08 μg/mL) and α-glucosidase enzymes (2.41±0.08 μg/ mL) by DZL. Both glucose-loaded normoglycemic rats and STZ-induced diabetic rats treated with DZL (200 mg/kg) exhibited a significant post-dose reduction in blood glucose levels (<em>P</em> &lt;0.01, 8 h and <em>P</em> &lt;0.001, 12 h) when compared to normal and diabetic control rats, respectively. These findings suggest that the presence of polyphenols in DZL might be responsible for antioxidant and antidiabetic properties and DZL could be a natural source as an herbal remedy for diabetes.</p>
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2021-02-01 10:54:30
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJEB/article/view/45722
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 59, ##issue.no## 02 (2021): IJEB [February 2021]
 
Language Note en