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Antitumor activity with no toxicity of propolis from Meghalaya, India in ascites Dalton’s lymphoma-bearing mice

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Title Antitumor activity with no toxicity of propolis from Meghalaya, India in ascites Dalton’s lymphoma-bearing mice
 
Creator Prasad, Surya Bali
Turnia, Ibanrikynti
 
Subject Cisplatin
Dalton’s lymphoma
Propolis
Sperm abnormality
Toxicity
 
Description 267-279
Propolis or bee glue is an important natural bee product that has been used by humans to meet the needs of health since ancient times. Despite its many valuable uses, scientific research on propolis is still limited. Despite rich traditional zootherapeutic knowledge of the people and affluent biodiversity of North-east India, almost no research study has been undertaken on the assessment of various biological properties of propolis from this region. Recently, the antibacterial and antitumor activity of the methanolic extract of propolis (MeOH-propolis) from Meghalaya was reported by us only. The present study was undertaken to further examine the antitumor activity and toxicity in ascites Dalton’s Lymphoma bearing mice itself and compare with that of cisplatin, a well established anticancer drug also known to cause different toxicities in the host. MeOH-propolis showed potent anticancer activity against ascites Dalton’s lymphoma. The assessment of various toxicity parameters such as hematotoxicity, nephrotoxicity, hepatotoxicity and sperm abnormality revealed that MeOH-propolis treatment did not develop any toxicity while cisplatin developed these toxicities in the host. It is suggested that the increasing antioxidative defense activity of the MeOH-propolis could be involved in its ability to avoid any toxicity in the host. The findings from the present study showing the combined action of MeOH-propolis as anticancer as well as its ability to stabilize various toxicity parameters in cancer-bearing mice suggest the possibility of using propolis as a natural alternative to chemotherapy to shun the side effects.
 
Date 2021-02-04T09:18:03Z
2021-02-04T09:18:03Z
2020-12
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscair.res.in/handle/123456789/56145
 
Language en_US
 
Relation Int. cl. (2015.01)-A61K 35/00, A61K 35/644
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJNPR Vol.11(4) [December 2020]