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<p style="text-align: justify;">Isolation, characterization, and biological evaluation of flavonols and 1,2-diphenylethanes from <em>Bauhinia vahlii</em></p>

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Title Statement <p style="text-align: justify;">Isolation, characterization, and biological evaluation of flavonols and 1,2-diphenylethanes from <em>Bauhinia vahlii</em></p>
 
Added Entry - Uncontrolled Name Ketha, Alekhya ; Pharmaceutical Chemistry Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, Andhra Pradesh, India
Vedula, Girija Sastry; Pharmaceutical Chemistry Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, Andhra Pradesh, India
Maratha Mandal Dental College, Belgaum, India
 
Uncontrolled Index Term Natural products chemistry; Ethanopharmacology; Bioactive natural products
Anticancer; Anti-gout; Anti-inflammatory; Antioxidant; Bauhinia vahlii; Sulforhodamine B assay.
 
Summary, etc. <p style="text-align: justify;">In this study, three known flavonols, namely kaempferol <strong>(1)</strong>, ombuin <strong>(2)</strong>, and quercetin <strong>(3)</strong>, and three known 1,2-diphenylethanes, namely 5-(2-hydroxyphenethyl)-3-methoxy-2-methylphenol <strong>(4)</strong>, 2-(3,5-dimethoxyphenethyl) phenol <strong>(5)</strong> and 2-(2-hydroxyphenethyl)-4,6-dimethoxyphenol <strong>(6) </strong>from the methanolic extract <strong>(ME)</strong> of <em>Bauhinia vahlii </em>were identified and sucessfully isolated. They were also evaluated for <em>in vitro</em> antioxidant, anti-inflammatory, anti-gout and anticancer effects. Compound <strong>3</strong> (26.00±2.17 µg/mL) showed an almost equivalent IC<sub>50</sub> value of standard drug (25.55±2.80 µg/mL) against superoxide free radicals. Moreover, compound <strong>3</strong> showed significant inhibition of COXs and 5-LOX enzymes, while compounds <strong>1, 2, 4</strong> and <strong>5</strong> exhibited good inhibition of XO enzymes. Except for compound <strong>5</strong>, all compounds showed a significant reduction of cell growth lysis of MCF-7, DLD-1, HeLa, and A549. Besides, all the metabolites and <strong>ME</strong> showed a very weak degree of specificity against NHME, indicates less toxicity to normal cells. The results suggest that <em>B. vahlii </em>can be a favourable natural source for the treatment of oxidative stress, inflammation, gout and cancer, and these actions are linked to the natural active compounds <strong>1, 3,</strong> <strong>4</strong> and <strong>6</strong>.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2021-02-08 15:23:32
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/38857
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 11, ##issue.no## 4 (2020): December 2020
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/38857/465520860
http://op.niscair.res.in/index.php/IJNPR/article/download/38857/465520863
http://op.niscair.res.in/index.php/IJNPR/article/download/38857/465520864
http://op.niscair.res.in/index.php/IJNPR/article/download/38857/465547911
 
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