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<p style="text-align: justify;"><em>In vitro </em>anticancer activity of silver nanoparticle synthesized from <em>Punica granatum </em>dried peel against cancer cell lines</p>

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Title Statement <p style="text-align: justify;"><em>In vitro </em>anticancer activity of silver nanoparticle synthesized from <em>Punica granatum </em>dried peel against cancer cell lines</p>
 
Added Entry - Uncontrolled Name Paarakh, M. Padmaa ; Department of Pharmacognosy, The Oxford College of Pharmacy, 6/9, I Main, Begur Road, Hongasandra, Bangalore 560 068, Karnataka, India
Jose, Preethy Ani; Department of Pharmaceutics, The Oxford College of Pharmacy, 6/9, I Main, Begur Road, Hongasandra, Bangalore 560 068, Karnataka, India
Rajiv Gandhi University of Health Sciences
 
Uncontrolled Index Term utilization of plants and animals in broader sense
Apoptosis; Cell Lines; Cell cycle; In vitro anticancer activity; Punica granatum; Silver nanoparticle.
 
Summary, etc. <p style="text-align: justify;">The main aim of the investigation was to screen the silver and gold nanoparticle synthesized from the methanol concentrate of <em>Punica granatum </em>for its <em>in vitro </em>anticancer activity against MCF 2, PC3, A-549, HeLa, and HepG2 cell lines. Silver and gold nanoparticles were prepared from methanol concentrate of <em>P. granatum </em>and nanoparticle synthesized was analyzed by UV and TEM analysis. The impact of nanoparticles synthesized on MCF-2, PC3, A-549, HeLa, and HepG2 disease cell lines was assessed by MTT colourimetric assay and the impact on cell cycle was assessed by flow cytometric method. After assessing the cytotoxicity effect, the impact of apoptosis was also analyzed. The TEM analysis showed the particle size of 25.56 and 22.02 nm for gold and silver nanoparticles respectively. The adequacy of silver nanoparticles synthesized from <em>P. granatum </em>against MCF-2, PC3, A-549, HeLa, and HepG2 cell line demonstrated that the hatching of malignancy cells decreased the suitability of PC-3 and A 549 cancer cells lines only with IC<sub>50</sub> values as 108.7 and 88.42 µg/mL respectively. Gold nanoparticles didn’t have any activity against all the cancer cell lines. Cell cycle analysis and apoptosis study showed that Silver nanoparticles are effective in controlling the cell cycle and blocking the apoptosis in all the cell lines used. <em>P. granatum </em>can be a very good anticancer drug for various cancer cell lines. All in all, <em>P. granatum </em>has a critical cell reinforcement movement and anticancer action.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2021-02-08 15:23:32
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/29583
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 11, ##issue.no## 4 (2020): December 2020
 
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