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<p style="text-align: justify;">Hepatoprotective activity of <em>Ficus semicordata</em> Buch.-Ham. ex Sm. leaves aqueous extract on D-galactosamine induced toxicity in HepG2 cell line</p>

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Title Statement <p style="text-align: justify;">Hepatoprotective activity of <em>Ficus semicordata</em> Buch.-Ham. ex Sm. leaves aqueous extract on D-galactosamine induced toxicity in HepG2 cell line</p>
 
Added Entry - Uncontrolled Name Gupta, Shashi ; Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar 361008, India
Ranade, Anagha ; Regional Ayurveda Institute for Fundamental Research (RAIFR), Kothrud, Pune, Maharashtra 411038, India
Gayakwad, Shivani ; Regional Ayurveda Institute for Fundamental Research (RAIFR), Kothrud, Pune, Maharashtra 411038, India
Acharya, Rabinarayan ; Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar 361008, India
Pawar, Sharad ; Regional Ayurveda Institute for Fundamental Research (RAIFR), Kothrud, Pune, Maharashtra 411038, India
Gujarat Ayurved University, Jamnagar, India
 
Uncontrolled Index Term Pharmacology, Hepatoprotective activity
D-galactosamine, Dexamethasone, Ficus semicordata Buch. Ham. ex Sm, Hepatoprotective, HepG2.
 
Summary, etc. <p style="text-align: justify;">The leaves of <em>Ficus semicordata </em>Buch-Ham.ex Sm., locally in North India is referred to as <em>Bhumi udumbara </em>have been reported for their traditional use to cure jaundice and various liver ailments. Despite its extensive usage in northeastern states of India, there is a lack of scientific substantiation on the safety and pharmacotherapeutic efficacy. The present study was carried out to evaluate the hepatoprotective activity of <em>F. semicordata </em>(FS) leaves aqueous extract on HepG2 cell line to validate its ethnic claim in the management of liver disorders. D-galactosamine induced HepG2 cell toxicity model was used to evaluate its hepatoprotective activity. The cells were treated with different concentrations of aqueous extracts and dexamethasone as a standard. MTT assay was performed to determine the % inhibition of hepatotoxicity. The result indicates that the toxicity induced by D-galactosamine is reduced by FS<em> </em>aqueous extract group which is better when compared with the standard drug. This study revealed the hepatoprotective potential of <em>F. semicordata </em>on HepG2 cell line</p><p style="text-align: justify;"><em>.</em></p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2021-02-08 15:23:32
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/27819
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 11, ##issue.no## 4 (2020): December 2020
 
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