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Electro-chemical oxidation and determination of granulocytosis risk inducing drug 4-aminoantipyrine at gold electrode

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Title Electro-chemical oxidation and determination of granulocytosis risk inducing drug 4-aminoantipyrine at gold electrode
 
Creator Gowda, Jayant I
Hanabaratti, Rohini M
Nandibewoor, Sharanappa T
 
Subject 4-Aminoantipyrine
Gold electrode
Electro-oxidation
Diffusion controlled process
Detection limit
Recovery study
 
Description 228-235
A voltammetric technique for electrochemical sensing and quantification of granulocytosis risk inducing metabolite of aminopyrine, 4-Aminoantipyrine (4-AAP) at gold electrode has been developed. The gold electrode shows excellent selectivity and sensitivity towards the oxidation of 4-AAP in phosphate buffer solution (PBS) of pH=3.0. It is observed from the electrochemical studies of scan rate that overall electrode process is diffusion controlled and pH effect suggests involvement of protons in electrochemical oxidation of 4-AAP. A linear current response towards the electrochemical oxidation of 4-AAP in the concentration range of 1.0 × 10-6 – 2.5 × 10−5 M is observed with limit of detection of 3.8 × 10-8 M (S/N = 3). The interference studies have shown that the gold electrode exhibited excellent selectivity in presence of large excess of interferents. The method is employed to recovery study of 4-AAP in spiked urine and serum samples.
 
Date 2021-02-11T06:06:25Z
2021-02-11T06:06:25Z
2021-02
 
Type Article
 
Identifier 0975-0975(Online); 0376-4710(Print)
http://nopr.niscair.res.in/handle/123456789/56198
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-A Vol.60A(02) [February 2021]