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2,4-Dinitrophenyl hydrazone derivatives as potent alpha amylase inhibitors

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Title 2,4-Dinitrophenyl hydrazone derivatives as potent alpha amylase inhibitors
 
Creator Yousaf, Muhammad
Hassan, Amir
Ahmad, Shakeel
Idrees, M
Adil, M
Zia, Huma
Haq, Mirajul
Faisal, Shah
Kainat
 
Subject Schiff base
2,4-dinitrophenyl hydrazone
Alpha amylase activity
Molecular docking
 
Description 277-282
In our current study thirteen new 2,4-dinitrophenyl hydrazone derivatives 1–13 have been evaluated for alpha amylase activity. The molecular docking results indicate that compounds potentially bind in the catalytic site of the enzyme with excellent result. Molecular Operating Environment (MOE) software was used for docking study. 2,4-Dinitrophenyl hydrazone 1-13 have been obtained under reflux conditions by reacting dinitrophenyl hydrazine in methanol with different aromatic as well as aliphatic aldehydes in the presence of acetic acid act as a catalyst. The current results have shown that compounds 5 (IC50 =12.16µg/mL), 6 (IC50 =15.03µg/mL), and 12 (IC50 =16.42 µg/mL) have been found to be the more potent alpha amylase inhibitors as compared to the standard acarbose (IC50 = 42.47µg/mL). These compounds may provide better leads for alpha amylase inhibitor and further assessment of these compounds can be of great help in the discovery of new antidiabetic drugs.
 
Date 2021-02-11T10:26:33Z
2021-02-11T10:26:33Z
2021-02
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/56212
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-B Vol.60B(02) [February 2021]