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2,4-Dinitrophenyl hydrazone derivatives as potent alpha amylase inhibitors<br />

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Title Statement 2,4-Dinitrophenyl hydrazone derivatives as potent alpha amylase inhibitors<br />
 
Added Entry - Uncontrolled Name Yousaf, Muhammad ; Department of Chemistry, Government Post Graduate College Mardan 23200, Pakistan
Hassan, Amir ; GOVT. POST-GRADUATE COLLEGE MARDAN
Ahmad, Shakeel ; Department of Chemistry, Abdul Wali Khan University Mardan 23200, Pakistan
Idrees, M ; Department of Chemistry, Abdul Wali Khan University Mardan 23200, Pakistan
Adil, M ; Department of Chemistry, Abdul Wali Khan University Mardan 23200, Pakistan
Zia, Huma ; Department of Chemistry, Abdul Wali Khan University Mardan 23200, Pakistan
Haq, Mirajul ; Department of Chemistry, Abdul Wali Khan University Mardan 23200, Pakistan
Faisal, Shah ; Department of Chemistry, Abdul Wali Khan University Mardan 23200, Pakistan
k, Kainat ; Department of Chemistry, Abdul Wali Khan University Mardan 23200, Pakistan
None
 
Uncontrolled Index Term Schiff base, 2,4-dinitrophenyl hydrazone, alpha amylase activity, molecular docking
 
Summary, etc. <p class="Abstract">In our current study thirteen new 2,4-dinitrophenyl hydrazone derivatives <strong>1–13</strong> have been evaluated for alpha amylase activity. The molecular docking results indicate that compounds potentially bind in the catalytic site of the enzyme with excellent result. <em>Molecular Operating Environment</em> (MOE) software was used for docking study. 2,4-Dinitrophenyl hydrazone <strong>1-13</strong> have been obtained under reflux conditions by reacting dinitrophenyl hydrazine in methanol with different aromatic as well as aliphatic aldehydes in the presence of acetic acid act as a catalyst. The current results have shown that compounds <strong>5</strong> (IC<sub>50 </sub>=12.16<em>µ</em>g/mL), <strong>6</strong> (IC<sub>50 </sub>=15.03<em>µ</em>g/mL), and <strong>12</strong> (IC<sub>50 </sub>=16.42 <em>µ</em>g/mL) have been found to be the more potent alpha amylase inhibitors as compared to the standard acarbose (IC<sub>50 </sub>= 42.47<em>µ</em>g/mL). These compounds may provide better leads for alpha amylase inhibitor and further assessment of these compounds can be of great help in the discovery of new antidiabetic drugs.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-02-15 15:57:41
 
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http://op.niscair.res.in/index.php/IJCB/article/view/29515
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 2 (2021): Indian Journal of Chemistry Section - B (IJCB)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/29515/465490716
http://op.niscair.res.in/index.php/IJCB/article/download/29515/465490884
http://op.niscair.res.in/index.php/IJCB/article/download/29515/465490885
 
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