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Investigation of cytotoxic effect of black mulberry (Morus nigra L.) fruit

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Title Investigation of cytotoxic effect of black mulberry (Morus nigra L.) fruit
 
Creator Dalkiliç, S
Dalkiliç, L K
İnci, Ş
Korkmaz, İ
Kırbağ, S
 
Subject Breast cancer
Cytotoxicity
Morus nigra L.
MTT
Prostate cancer
 
Description 54-58
The aim of this study was to determine the cytotoxic effect of black mulberry fruit extract (Morus nigra L.) on human breast cancer (MDA-MB-231) and prostate cancer (PC3) cell lines. The extract prepared from mulberry (M. nigra) fresh fruit was applied to cancer cell lines in 5 different v/v concentrations (10%, 4%, 2%, 1.33% and 1%) for 72 h. At the end of the incubation period, cell viability was determined by MTT [3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide] assay. Results were compared with negative and positive control groups. The effect of mulberry (M. nigra) fruit extract on cell viability was determined depending on the concentration applied; extract showed a significant cytotoxic effect on PC3 cell line at the 10% concentration compared to the control group, but not detected any effect at 4%, 2%, 1.33% and 1% concentrations. In the MDA-MB-231 cell line, there was a high cytotoxic effect at a concentration of 10% compared to the control group, while a lower effect was observed at 4%, 2%, 1.33% and 1% concentrations. The data obtained from the study showed that extract prepared from black mulberry fruit has cytotoxic effect especially against breast cancer cells.
 
Date 2021-02-24T07:49:12Z
2021-02-24T07:49:12Z
2021-01
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscair.res.in/handle/123456789/56303
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJTK Vol.20(1) [January 2021]