Record Details

Polysilicon Field Effect Transistor Biosensor for the Detection of Cardiac Troponin-I (cTnI)

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Polysilicon Field Effect Transistor Biosensor for the Detection of Cardiac Troponin-I (cTnI)
 
Creator Prajesh, Rahul
Goyal, Vinay
Kakkar, Saloni
Sharma, Jyayashi
Alam, M.A.
Maurya, Ranjan Kumar
Bhalla, Vijayender
Agarwal, A.
 
Subject QR Microbiology
 
Description A highly sensitive and robust polysilicon Field Effect transistor (SiFET) has been developed for the detection of an gold standard biomarker of myocardial infarction (AMI) Cardiac Troponin I (cTnI). This paper reports a polysilicon FET device integrated with a thin film of gold layer as a gate terminal which is biofunctionalized with specific cTnI binding single stranded DNA receptor aptamer to detect cTnI. The reported SiFET is fabricated using standard microfabrication unit processes. The detailed characterization of reported device is performed and thoroughly discussed at different stages of device development. The assessment of bio-interface is also studied using various surface characterization techniques such as Raman spectroscopy, Atomic force microscopy (AFM) and Contact angle measurements. The experimental results showed the significant response for cTnI concentration as low as 0.1 ng ml(-1) for label free detection.
 
Publisher ELECTROCHEMICAL SOC INC
 
Date 2021-02-01
 
Type Article
PeerReviewed
 
Relation https://iopscience.iop.org/article/10.1149/1945-7111/abdde6#:~:text=A%20highly%20sensitive%20and%20robust,Cardiac%20Troponin%20I%20(cTnI).&text=The%20experimental%20results%20showed%20the,ml%20for%20label%20free%20detection.
http://crdd.osdd.net/open/2652/
 
Identifier Prajesh, Rahul and Goyal, Vinay and Kakkar, Saloni and Sharma, Jyayashi and Alam, M.A. and Maurya, Ranjan Kumar and Bhalla, Vijayender and Agarwal, A. (2021) Polysilicon Field Effect Transistor Biosensor for the Detection of Cardiac Troponin-I (cTnI). JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 168 (2). ISSN 0013-4651