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Synthesis, characterization, antimicrobial and DNA cleavage study of organoantimony(III) and organoarsenic(III) complexes with monofunctional bidentate Schiff base

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Title Synthesis, characterization, antimicrobial and DNA cleavage study of organoantimony(III) and organoarsenic(III) complexes with monofunctional bidentate Schiff base
 
Creator Kumari, Anita
Meena, Ramhari
Singh, R V
Fahmi, Nighat
 
Subject Antimicrobial activity
DNA cleavage activity
Organoantimony(III) and Organoarsenic(III) complexes
Sulfur and nitrogen donor system
 
Description 341-347
A series of mononuclear organoantimony(III) and organoarsenic(III) complexes of bidentate Schiff base [2-(2-fluorophenyl)methylene]hydrazinecarbothioamide (LH) have been synthesized by the reaction of Ph3Sb and Ph3As with ligand in 1:1 and 1:2 molar ratios. All the synthesized compounds were characterized by elemental analyses, melting point determinations and a combination of electronic, IR, 1H NMR, 13C NMR and X-ray diffraction studies. These studies have shown that the ligand coordinated to the antimony and arsenic in a monobasic bidentate manner through sulfur and nitrogen donor system. Thus, a tetra-coordinated and a penta-coordinated environment around the antimony and arsenic atom have been proposed for 1:1 and 1:2 complexes, respectively. All the complexes and parent ligand have been screened for their antimicrobial activity on several pathogenic fungi and bacteria and are found to possess appreciable fungicidal and bactericidal properties. Further, the ligand and its corresponding metal complexes have been tested for their DNA cleavage activity by the gel electrophoresis and the results revealed that the complexes are better cleaving agents than ligand.
 
Date 2021-03-03T04:22:03Z
2021-03-03T04:22:03Z
2021-03
 
Type Article
 
Identifier 0975-0975(Online); 0376-4710(Print)
http://nopr.niscair.res.in/handle/123456789/56381
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-A Vol.60A(03) [March 2021]