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Synthesis and biological evaluation of novel 3-aryl-4-methoxy N-alkyl maleimides

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Title Synthesis and biological evaluation of novel 3-aryl-4-methoxy N-alkyl maleimides
 
Creator Gosavi, Kirankumar S
Mahale, Keshao A
Patil, Nilesh S
Patil, Sambhaji V
 
Subject Maleimide
Maleic anhydride
MIC
Antifungal
Antibacterial
 
Description 473-478
In the present investigation, a series of 3-aryl-4-methoxy N-alkyl maleimide 5a-l have been synthesized and screened for their antimicrobial activity against one Gram positive bacteria (S. aureus), one Gram negative bacteria (E. coli) and fungal strains (C. albicans, C. tropicalis,  A. niger and A. clavatus). The structures of the compounds have been substantiated by their IR, NMR, mass and elemental analysis. The minimum inhibitory concentrations (MICs) of synthesized maleimides have been determined by broth microdilution method. Of the newly synthesized maleimides, compounds 5c, 5f, 5h, 5i, 5k and 5l registered significant activity against the tested microorganisms.
 
Date 2021-03-03T04:48:40Z
2021-03-03T04:48:40Z
2021-03
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/56384
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-B Vol.60B(03) [March 2021]