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Synthesis and antimicrobial activity of chalcone containing polystyrene

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Title Synthesis and antimicrobial activity of chalcone containing polystyrene
 
Creator Rain, Farhana Sumi
Hasan, Tariqul
Chowdhury, Samiul Islam
Ali, Roushown
 
Subject Chalcone
4-propargyloxychalcone
Azide end-functional polystyrene
Chalcone containing polystyrene
Click reaction
Antibacterial activity
 
Description 456-464
Three different 4-propargyloxychalcones have been prepared starting from 4-propargyloxy benzaldehyde and chalcones with proper chemical transformation. Polystyrenes containing biologically active chalcone moiety in their structures have been successfully synthesised by the Click reaction from the 4-propargyloxychalones (terminal alkyne) and azido end-functional polystyrene (PS-N3). All the desired products have been obtained with good yield and purity. The structure of the 4-propargyloxychalcones and the chalcone containing polystyrenes have been characterized by FT-IR, 1H NMR and UV-Vis spectroscopy. The antibacterial activity of the synthesized 4-propargyloxychalcones their polystyrene derivatives have been evaluated against two bacterial strains, Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative). The results reveal that the tested chalcones and their polystyrene derivatives have moderate antimicrobial activity.
 
Date 2021-03-03T04:52:55Z
2021-03-03T04:52:55Z
2021-03
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/56386
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-B Vol.60B(03) [March 2021]