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Synthesis, in vitro biological evaluation and molecular docking study of coumarin-1,4-dihydropyridine derivatives as potent anti-inflammatory agents

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Title Synthesis, in vitro biological evaluation and molecular docking study of coumarin-1,4-dihydropyridine derivatives as potent anti-inflammatory agents
 
Creator Madar, Jyoti M
Shastri, Lokesh A
Shastri, Samundeeswari L
Holiyachi, Megharaja
Naik, Nirmala S
Gudimani, Parashuram
Pawar, Varsha
Shettar, Arun K
Joshi, Shrinivas D
Sungar, Vinay A
 
Subject Coumarin-1,4-dihydropyridine
Antimicrobial activity
Anti-inflammatory activity
Molecular docking study
Green protocol
 
Description 418-432
The green chemistry approach provides for the synthesis of coumarin-1,4-dihydropyridine scaffolds 6a-o via sequential multicomponent reaction using catalytic amount of triethylamine (TEA). These new coumarin scaffolds have been successfully explored for the effective inflammatory as well as microbial infection inhibitors. The antimicrobial activity results of the title compounds have shown potent activity against both gram positive and gram negative bacterial, and fungal stains. Additionally, anti-inflammatory activity of all the compounds has been found to be quite promising in comparison with standard Diclofenac sodium. Furthermore, the in silico docking study has been performed for all the compounds with S. aureus DNA gyrase and cyclooxygenase-2 (PDB ID 4PH9). The computational results are in good agreement with the in vitro antibacterial and anti-inflammatory experimental results.
 
Date 2021-03-03T05:02:07Z
2021-03-03T05:02:07Z
2021-03
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/56390
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-B Vol.60B(03) [March 2021]