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<p>Vasorelaxation to Eugenol, Curcumin and Nanocurcumin is mediated by differential  augmentation of Na<sup>+</sup>, K<sup>+</sup>-ATPase activity in middle uterine artery of <em>Capra hircus</em>.</p><p class="Bodytext"> </p>

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Title Statement <p>Vasorelaxation to Eugenol, Curcumin and Nanocurcumin is mediated by differential  augmentation of Na<sup>+</sup>, K<sup>+</sup>-ATPase activity in middle uterine artery of <em>Capra hircus</em>.</p><p class="Bodytext"> </p>
 
Added Entry - Uncontrolled Name Parija, Subas Chandra; Orissa University of Agriculture &Technology
Jandhyam, H ; Department of Pharmacology &Toxicology, College of Veterinary Science and Animal Husbandry, Orissa University of Agriculture and Technology, Bhubaneswar 751 003, Orissa, India
Mohanty, B P; Fishery Resource & Environmental Management (FREM) Division, ICAR-Central Inland Fisheries Research Institute, Barrack pore, Kolkata 700 120, West Bengal, India
UGC, Govt of India
 
Uncontrolled Index Term Curcumin, Eugenol, Goat uterine artery, Na+, K+-ATPase, Nanocurcumin
 
Summary, etc. Sodium-potassium ATPase (Na, K-ATPase) is an integral protein universally distributed in the plasma membrane of all eukaryotic cells. It regulates trans-epithelial sodium ion transport, muscle contraction, nerve excitability, secretary functions and intracellular signaling. We investigated the mechanism of vasorelaxation effect of Eugenol, Curcumin and Nanocurcumin in the middle uterine artery (MUA) of goat to evaluate their possible therapeutic potential in hypertension during pregnancy or pre-eclampsia. The UA rings were isometrically contracted by K+-free MKHS to plateau and relaxed with KCl (10 μM-10 mM) following standard protocol. The K+ -vasorelaxation response (VR) was taken either in presence of ouabain with or without Eugenol/Curcumin/Nanocurcumin (10 μM). Rmax (maximum % vasorelaxation) of K+-induced VR-curve elicited in UA rings was reduced (from 6.90% and 26.55%) to 4-5% in presence of Ouabain in both NP and P goats. Rmax obtained from KVR curve elicited in UA rings were augmented in presence of Eugenol (NP: 16.22%, P: 42.67%) or Curcumin (NP:21.23%, P:35.49%) or Nanocurcumin (NP:6.91%, P:34.88%). K+ vasorelaxation was inhibited in presence of Ouabain and Eugenol/ Curcumin/Nanocurcumin (Rmax: 6.11%, 9.18%, 4.11% in non-P, respectively) and (Rmax: 5.40%, 3.39%, 6.00% in P, respectively). The results indicated that (i) there is increased function of α1- Na+, K+-ATPase in UA of P goats (ii) Eugenol, Curcumin and Nano-curcumin differentially augmented the function and expression of α1 isoenzymes of sodium pump in UA of non-P and P goats. Thus, the polyphenols potentially activate α1 isoenzymes of Na+-K+-ATPase and could possibly be useful as therapeutic in hypertension during pregnancy.
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2021-03-03 16:09:58
 
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http://op.niscair.res.in/index.php/IJTK/article/view/29617
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 20, ##issue.no## 1 (2021): Indian Journal of Traditional Knowledge
 
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