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<p>Investigation of Cytotoxic Effect of Black Mulberry (<em>Morus nigra </em>L.) Fruit<strong></strong></p>

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Title Statement <p>Investigation of Cytotoxic Effect of Black Mulberry (<em>Morus nigra </em>L.) Fruit<strong></strong></p>
 
Added Entry - Uncontrolled Name Dalkilic, Semih ; Firat University
Dalkilic, Lütfiye Kadioglu; Firat University
İnci, Sule ; Firat University
Korkmaz, İsmail ; Firat University
Kirbag, Sevda ; Firat University
 
Uncontrolled Index Term Breast cancer; Cytotoxicity; Morus nigra L.; MTT assay; Prostate cancer
 
Summary, etc. <p>The aim of this study was to determine the cytotoxic effect of black mulberry fruit extract (<em>Morus nigra</em> L.) on human breast cancer (MDA-MB-231) and prostate cancer (PC3) cell lines. The extract prepared from mulberry (<em>M. nigra</em>) fresh fruit was applied to cancer cell lines in 5 different concentrations (1/10, 1/25, 1/50, 1/75 and 1/100) for 72 hours. At the end of the incubation period, cell viability was determined by MTT (3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide) assay. Results were compared with negative and positive control groups. The effect of mulberry (<em>M. nigra</em>) fruit extract on cell viability was determined depending on the concentration applied; extract showed a significant cytotoxic effect on PC3 cell line at the 1/10 concentration compared to the control group, but not detected any effect at 1/25, 1/50, 1/75 and 1/100 concentrations. In the MDA-MB-231 cell line, there was a high cytotoxic effect at a concentration of 1/10 compared to the control group, while a lower effect was observed at 1/25, 1/50, 1/75 and 1/100 concentrations. The data obtained from the study showed that extract prepared from black mulberry fruit has cytotoxic effect especially against breast cancer cells.</p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2021-03-03 16:09:58
 
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http://op.niscair.res.in/index.php/IJTK/article/view/29335
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 20, ##issue.no## 1 (2021): Indian Journal of Traditional Knowledge
 
Language Note en