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In vitro anticancer and apoptotic activity of edible mushroom Lepista nuda (Bull.) Cooke on leukemia and breast cancer compared with protocatechuic acid, paclitaxel and doxorubicin

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Title In vitro anticancer and apoptotic activity of edible mushroom Lepista nuda (Bull.) Cooke on leukemia and breast cancer compared with protocatechuic acid, paclitaxel and doxorubicin
 
Creator Özmen, Ali
Değirmenci, Esin Hafize
 
Subject Cancer
Cell proliferation
Macro fungi
Tumor
 
Description 147-152
Macro fungi are used as food and for therapy for centuries. One such fungus Lepista nuda (Bull.) Cooke is reported to exhibit many biological activities while other species viz. Lepista inversa and L. sordida possess active substances. In this study, we prepared extractions depended on polarity increase from the edible mushroom Lepista nuda and studied its action on HL60 (leukemia) and MCF7 (breast cancer) cancer cell lines., We used PCA (protocatechuic acid), paclitaxel and doxorubicin as positive controls. Methanol extract was found effective on both cell lines. The extract showed fairly significant (IC50 ~15 mg/mL) of biologic activity compared with drugs protocatechuic acid, paclitaxel and doxorubicin against HL-60 cell line with regard to both proliferation and apoptotic effects (>%75).
 
Date 2021-03-09T05:07:27Z
2021-03-09T05:07:27Z
2021-03
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/56401
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJEB Vol.59(03) [March 2021]