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Pharmacological evaluation for anti-bacterial and anti-inflammatory potential of polymeric microparticles

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Title Pharmacological evaluation for anti-bacterial and anti-inflammatory potential of polymeric microparticles
 
Creator Singh, Ritika
Prasad, Jhakeshwar
Satapathy, Trilochan
Jain, Parag
Singh, Shalini
 
Subject Acacia arabica
Dextran
Ethyl cellulose
Microparticle
Paw edema
 
Description 156-161
The objective of the study was to evaluate anti-bacterial and anti-Inflammatory activities of polymeric microparticles. In vitro antibacterial activity was performed for prepared microparticles followed by in vivo anti-inflammatory activity on rats. From the present study, it was observed that the microparticles developed were appropriate in their shape and uniform size. The topography of SEM studies revealed that, the microparticles were smooth-surfaced. The result of antibacterial activity indicated that the formulation has not exhibited any zone of inhibition against the various strains of bacteria used for this study. The result of anti-inflammatory activity (Dextran induced paw edema) exhibits that, the formulations possess the inhibitory potential for various inflammatory mediators thereby reduces the inflammation in paws. From the results, it can be concluded that Acacia arabica microparticles is showing significant Anti-inflammatory activity after 6 h than conventional dosage form.
 
Date 2021-03-11T07:11:44Z
2021-03-11T07:11:44Z
2021-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscair.res.in/handle/123456789/56484
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.58(2) [April 2021]