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<p>Synthesis, <em>in silico</em> pharmacokinetic analysis and anticancer activity evaluation of benzothiazole-triazole hybrids</p><p> </p>
Online Publishing @ NISCAIR
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| Authentication Code |
dc |
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| Title Statement |
<p>Synthesis, <em>in silico</em> pharmacokinetic analysis and anticancer activity evaluation of benzothiazole-triazole hybrids</p><p> </p> |
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| Added Entry - Uncontrolled Name |
Rawat, Srishti ; Department of Chemistry, University of Delhi, Delhi 110 007, India Rawat, Diwan Singh; Department of Chemistry, University of Delhi, Delhi 110 007, India Negi, Beena ; Gargi College, University of Delhi, Delhi 110 049, India UGC |
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| Uncontrolled Index Term |
2-Aminobenzothiazole, triazole, renal cancer, hybrid, click chemistry |
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| Summary, etc. |
<p>Over the past decade, a variety of benzothiazole derivatives have been reported with promising anticancer activity. Benzothiazole and its analogues are capable of acting on a number of molecular targets and thus exerting their anticancer activity. To further develop benzothiazole derivatives as anticancer agents, we attempted to design and synthesize a library of benzothiazole-triazole derivatives. The synthesized hybrid compounds have been selected by National Cancer Institute, USA for the <em>in vitro</em> activity evaluation against 60 human cancer cell lines in a one dose screening panel. Most of the synthesized compounds showed 60-80% growth rate against renal cancer cell line UO-31.</p> |
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| Publication, Distribution, Etc. |
Indian Journal of Chemistry -Section B (IJC-B) 2021-03-16 16:32:53 |
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| Electronic Location and Access |
application/pdf application/pdf http://op.niscair.res.in/index.php/IJCB/article/view/38659 |
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| Data Source Entry |
Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 3 (2021): Indian Journal of Chemistry- Section-B, (IJCB) |
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| Language Note |
en |
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| Nonspecific Relationship Entry |
http://op.niscair.res.in/index.php/IJCB/article/download/38659/465520179 http://op.niscair.res.in/index.php/IJCB/article/download/38659/465520180 http://op.niscair.res.in/index.php/IJCB/article/download/38659/465521534 http://op.niscair.res.in/index.php/IJCB/article/download/38659/465521536 |
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