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<p>Synthesis and anticonvulsant activity of some 1,4-dihydropyridine derivatives</p><p> </p>

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Title Statement <p>Synthesis and anticonvulsant activity of some 1,4-dihydropyridine derivatives</p><p> </p>
 
Added Entry - Uncontrolled Name Begum, Safia ; Medicinal Chemistry Research Division, Department of Pharmaceutical Chemistry, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal 506 001, India
Sirisha, Kalam ; Medicinal Chemistry Research Division, Department of Pharmaceutical Chemistry, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal 506 001, India
Vaagdevi College of Pharmacy
 
Uncontrolled Index Term 1,4-Dihydropyridine, Hantzsch method, pentylenetetrazole, anticonvulsant, synthesis
 
Summary, etc. <p class="Abstract">A series of asymmetrical 4-alkyl/aryl-2,6-dimethyl-3-N-(aryl/heteroaryl)-carbamoyl-5-ethoxycarbonyl-1,<br /> 4-dihydropyridines <strong>3a-d</strong> and symmetrical 4-alkyl/aryl-2,6-dimethyl-3,5-bis-(ethoxycarbonyl)-1,4-dihydropyridines <strong>4a</strong> and <strong>4b</strong> have been prepared by the condensation of various benzaldehydes, ethylacetoacetate, 2-aminopyridine or <em>p</em>-toludine in ethanol (Hantzch method). The structures of all the synthesized 1,4-dihydropyridine derivatives have been confirmed by spectral data (IR, <sup>1</sup>H NMR) and elemental analysis. Compounds <strong>3a-c</strong>, <strong>4a </strong>and <strong>4b</strong> (10 mg/kg) have been evaluated for their anticonvulsant effect against pentylenetetrazole- induced convulsions with phenytoin (4 mg/kg) as the standard. The anticonvulsant potential of the newly synthesized compounds have been assessed on the basis of increase in latency (onset time) to induce convulsions; decrease in number of convulsions and increase in latency of death compared to control and standard.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-03-16 16:32:53
 
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http://op.niscair.res.in/index.php/IJCB/article/view/32259
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 3 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
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http://op.niscair.res.in/index.php/IJCB/article/download/32259/465499521
 
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