Record Details

Wound healing potency of Hemigraphis alternata (Burm.f) T. Anderson leaf extract (HALE) with molecular evidence

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Wound healing potency of Hemigraphis alternata (Burm.f) T. Anderson leaf extract (HALE) with molecular evidence
 
Creator Sreekumar, Divyaa
Bhasker, Salini
Devi, Ponnuswamy Renuka
Mohankumar, C
 
Subject Anti-inflammatory
Antioxidant activity
Murikootti
Plasminogen Activator Inhibitor 1
Purple waffle plant
Red Ivy
Traditional medicine
Transforming growth factor beta 1
 
Description 236-245
Hemigraphis alternata (Burm.f) T. Anderson, commonly called as Red Ivy or Purple waffle plant and locally, Murikootti (Malayalam), is well known traditionally for its therapeutic effect in wound healing. Besides the analytical and biochemical evidence, more investigations at molecular level is inevitable for highlighting the healing effect of the herbal drug. In the present study, we have demonstrated the wound healing effect of H. alternata by in vitro cell line and animal model experiments using the Hemigraphis alternata leaf extract (HALE). The cell survival ability, cell proliferation and migration of cells in scratch wounds leading to wound closure were evident from the data by HALE treatment. Based on the wound closure observed in scratch wounds, the marker genes of wound healing PAI-1 and TGF-β1were analyzed by qPCR. The concentration and the expression fold were determined in 3T3-L1 and L6 cell lines treated with HALE. The concentration of marker gene of wound healing PAI-1 and TGF-β1showed significant increase in cell line cultures of 3T3-L1 and L6 cells treated with different concentrations of HALE (P
 
Date 2021-03-31T06:32:05Z
2021-03-31T06:32:05Z
2021-04
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/56560
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJEB Vol.59(04) [April 2021]