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<p style="text-align: justify;">Determination of bioactive phytochemicals, antioxidant and anti-inflammatory activity of <em>Colchicum autumnale</em> L. (<em>Suranjanshireen</em>)</p>

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Title Statement <p style="text-align: justify;">Determination of bioactive phytochemicals, antioxidant and anti-inflammatory activity of <em>Colchicum autumnale</em> L. (<em>Suranjanshireen</em>)</p>
 
Added Entry - Uncontrolled Name Hailu, Temesgen ; Department of Applied Chemistry, Delhi Technological University, Shahbad Daulatpur, Main Bawana Road, Delhi-110042, India
Sharma, Ratnika ; Department of Biotechnology, Guru Gobind Singh Indraprastha University, Sector-16C, Dwarka, Delhi 110078, India
Mann, Sonia ; CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi110007, India
Gupta, Promila ; Department of Biotechnology, Guru Gobind Singh Indraprastha University, Sector-16C, Dwarka, Delhi 110078, India
Gupta, Rajinder K.; Department of Applied Chemistry, Delhi Technological University, Shahbad Daulatpur, Main Bawana Road, Delhi-110042, India
Rani, Archna ; Department of Applied Chemistry, Delhi Technological University, Shahbad Daulatpur, Main Bawana Road, Delhi-110042, India
Ministry of Education, Ethiopia
 
Uncontrolled Index Term Anti-inflammatory activity; Antioxidant; GC-MS analysis; ICP-MS analysis; UHPLC-QExactiveOrbitrap analysis.
 
Summary, etc. <p style="text-align: justify;">In Unani System of Medicine <em>Suranjanshireen</em> (<em>Colchicum autumnale</em> L.) is primarily used for the treatment of arthritis, and it belongs to the family of Liliaceae. The current investigation was conducted to evaluate the phytochemical constituents, anti-oxidant, and anti-inflammatory activity of <em>C. autumnale</em> L. Anti-oxidant activity was done using 2, 2'-azinobis (3-ethyl benzothiazoline-6-sulfonic acid), and 2, 2-diphenyl-1-picrylhydrazyl free radical scavenging test. The bioactive compounds of the extracts of <em>C. autumnale </em>were identified by GC-MS and UHPLC-QExactiveOrbitrap. Docking studies were carried out for anti-inflammatory activity.The subjective phytochemicals examination demonstrated the existence of phenols, flavonoids, glycosides, and terpenoids. Whereas the quantitative investigation indicated dichloromethane extract contains the maximum number of phenolic and flavonoids constituents and demonstrated the highest antioxidant activity. GC-MS, and UHPLC- QExactiveOrbitrap investigation of the extracts confirmed the existence of bioactive compounds. Docking analysis revealed that colchicoside (3 demethyl colchicine glucoside) inhibits IL-6 having binding energy -7.1 kcal/mol with an RMSD value of 0.00. Phytochemicals, antioxidant, GC-MS, UHPLC- QExactiveOrbitrap analysis and molecular docking results revealed that the compounds presented in <em>C. autumnale</em> L extracts were accountable for numerous therapeutic uses, for instance, antioxidant, and anti-inflammatory activities.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2021-04-09 16:24:48
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/38305
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 12, ##issue.no## 1 (2021): March 2021
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/38305/465519093
http://op.niscair.res.in/index.php/IJNPR/article/download/38305/465519094
http://op.niscair.res.in/index.php/IJNPR/article/download/38305/465519095
http://op.niscair.res.in/index.php/IJNPR/article/download/38305/465519096
 
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