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Protective effect of <em>Abies pindrow</em> on dextran sulphate sodium induced ulcerative colitis in rats

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Title Statement Protective effect of <em>Abies pindrow</em> on dextran sulphate sodium induced ulcerative colitis in rats
 
Added Entry - Uncontrolled Name Patel, Jignesh I.; Pharmacology Department, B. K. Mody Government Pharmacy College, Bhavnagar Road, Rajkot 360003, Gujarat, India
Sanja, Suresh D; Pharmacology Department, B. K. Mody Government Pharmacy College, Bhavnagar Road, Rajkot 360003, Gujarat, India
B. K. Mody Government Pharmacy College, Rajkot, Gujarat, India
 
Uncontrolled Index Term Evaluation of the effects of medicinal plants on ulcerative colitis,
Abies pindrow; Anti-inflammatory action; Antioxidant action; DSS; Ulcerative colitis.
 
Summary, etc. <p style="text-align: justify;">The present study was designed to evaluate the protective effect of the leaves of <em>Abies pindrow </em>in dextran sulphate sodium (DSS) induced ulcerative colitis in rats in an attempt to search for a safe, effective, and economic treatment of ulcerative colitis. Petroleum ether extract of leaves of <em>A. pindrow </em>(PEEAP)was used and its phytochemical screening was performed. Dextran sulphate sodium induced ulcerative colitis model was used for the induction of disease. Rats were divided into six groups (n=6) namely, vehicle control, disease control, standard group (Sulphasalazine – 50mg/kg) and test group (PEEAP – 100, 200 &amp; 400 mg/kg). Disease activity index (DAI) was recorded daily from day 6 onward. After 11 days, animals were sacrificed and evaluated for colon mucosal damage index (CMDI) and the level of myeloperoxidase activity (MPO), malondialdehyde activity (MDA), Super oxide dismutase (SOD), catalase in the homogenized colon tissue. The animal treated with PEEAP (400 mg/kg) showed significant higher colon length than the disease control group. CMDI were found to be significantly lower in the treatment group as compared to the disease group. DAI was found to be significantly lower in the treatment group as compared to the diseased control group. It also showed a lower level of MPO and MDA and a higher level of SOD and catalase than those observed in the disease group. PEEAPsignificantly reduced the severity of the ulcerative colitis produced by DSS. The anti-inflammatory, anti-ulcer and antioxidant activity of this plant might be responsible for its protective role in ulcerative colitis. Further studies are suggested to isolate the active principle responsible for the activity and necessary to confirm the exact mechanism of action.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2021-04-09 16:24:48
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/27323
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 12, ##issue.no## 1 (2021): March 2021
 
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