Record Details

<p style="text-align: justify;">Gallic acid-loaded microemulsion and microemulsion gel: Development, characterization, and evaluation of antioxidant effectiveness</p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p style="text-align: justify;">Gallic acid-loaded microemulsion and microemulsion gel: Development, characterization, and evaluation of antioxidant effectiveness</p>
 
Added Entry - Uncontrolled Name Eren Böncü, Tuğba ; Department of Pharmaceutical Technology, Erciyes University, Kayseri 38039, Turkey
Yücel, Çiğdem ; Department of Pharmaceutical Technology, Erciyes University, Kayseri 38039, Turkey
Şeker Karatoprak, Gökçe ; Department of Pharmacognosy, Faculty of Pharmacy, Erciyes University, Kayseri 38039, Turkey
Takır, Esranur ; Department of Pharmaceutical Technology, Erciyes University, Kayseri 38039, Turkey
 
Uncontrolled Index Term Antioxidant effect; Cytotoxicity; Drug delivery system; Gallic acid; Microemulsion gel; Microemulsion.
 
Summary, etc. <p style="text-align: justify;">In this study, it was aimed to develop, characterize, and improve the antioxidant activity of gallic acid (GA) by formulating it into microemulsion (ME) and microemulsion gel (MEg). Blank MEs were prepared using different proportions of oil/water/surfactant, which provide stable and transparent ME production. Their droplet sizes, zeta potentials and stabilities after holding, centrifugation, and freeze-thawing processes were determined. F2 and F5 coded MEs were selected among the blank MEs and GA was loaded into these formulations. Besides the characterization studies, pH and viscosity measurement, <em>in vitro</em> release, cytotoxicity test, cell permeation, and antioxidant activity studies were performed. <em>In vitro</em> released amount of GA was enhanced by formulating it into ME and MEg at the end of six hours and it showed a scavenging effect of DPPH<sup>●</sup> and ABTS<sup>●+</sup> radicals. In conclusion, increased efficacy, reduced toxicity, and prolonged antioxidant activity have been achieved with the use of new, non-toxic, and stable ME and MEg loaded with GA and it is thought that these formulations create the potential for topical application.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2021-04-09 16:24:48
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJNPR/article/view/25636
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 12, ##issue.no## 1 (2021): March 2021
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/25636/465479948
http://op.niscair.res.in/index.php/IJNPR/article/download/25636/465495852
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed underCreative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2012. The Council of Scientific &amp; Industrial Research, New Delhi.