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Determination of bioactive phytochemicals, antioxidant and anti-inflammatory activity of Colchicum autumnale L. (Suranjanshireen)

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Title Determination of bioactive phytochemicals, antioxidant and anti-inflammatory activity of Colchicum autumnale L. (Suranjanshireen)
 
Creator Hailu, Temesgen
Sharma, Ratnika
Mann, Sonia
Gupta, Promila
Gupta, Rajinder K.
Rani, Archna
 
Subject Anti-inflammatory activity
Antioxidant
GC-MS analysis
ICP-MS analysis
UHPLC-QExactiveOrbitrap analysis
 
Description 52-60
In Unani System of Medicine Suranjanshireen (Colchicum autumnale L.) is primarily used for the treatment of arthritis, and it belongs to the family of Liliaceae. The current investigation was conducted to evaluate the phytochemical constituents, anti-oxidant, and anti-inflammatory activity of C. autumnale L. Anti-oxidant activity was done using 2, 2'-azinobis (3-ethyl benzothiazoline-6-sulfonic acid), and 2, 2-diphenyl-1-picrylhydrazyl free radical scavenging test. The bioactive compounds of the extracts of C. autumnale were identified by GC-MS and UHPLC-QExactiveOrbitrap. Docking studies were carried out for anti-inflammatory activity.The subjective phytochemicals examination demonstrated the existence of phenols, flavonoids, glycosides, and terpenoids. Whereas the quantitative investigation indicated dichloromethane extract contains the maximum number of phenolic and flavonoids constituents and demonstrated the highest antioxidant activity. GC-MS, and UHPLC- QExactiveOrbitrap investigation of the extracts confirmed the existence of bioactive compounds. Docking analysis revealed that colchicoside (3 demethyl colchicine glucoside) inhibits IL-6 having binding energy -7.1 kcal/mol with an RMSD value of 0.00. Phytochemicals, antioxidant, GC-MS, UHPLC- QExactiveOrbitrap analysis and molecular docking results revealed that the compounds presented in C. autumnale L extracts were accountable for numerous therapeutic uses, for instance, antioxidant, and anti-inflammatory activities.
 
Date 2021-04-08T08:48:20Z
2021-04-08T08:48:20Z
2021-03
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscair.res.in/handle/123456789/56762
 
Language en_US
 
Relation Int. cl. (2015.01)-A61K 36/00, A61K 36/896, A61P 29/00, A61P 39/00
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJNPR Vol.12(1) [March 2021]