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Synthesis and crystal structures of 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone (L) and its metal complexes: Anticancer activity of [Cu(L)(OAc)]

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Title Synthesis and crystal structures of 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone (L) and its metal complexes: Anticancer activity of [Cu(L)(OAc)]
 
Creator Biswas, Chinmoy
Chatterjee, Arnab
Sreekumar, Sreelekshmi
Kiran, Manikantan Syamala
Ghosh, Rajarshi
 
Subject Cu(II)
Zn(II)
Thiosemicarbazone
X-ray structure
Anticancer activity
 
Description 531-537
Synthesis and structural characterization of N(4)-substituted 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone (L) and its two metal complexes [Cu(L)(OAc)] (1) and [ZnL(OAc)]2 (2) are reported. Between the two complexes 1 is found to have good anticancer activity against Human lung cancer cell line (A549). Fluorescence microscopy finds the formation of reactive oxygen species on treatment of the cancer cells with 1. The IC50 value of the complex is measured as 0.72 mM which is lower than that of cisplatin against A549.
 
Date 2021-04-09T11:00:26Z
2021-04-09T11:00:26Z
2021-04
 
Type Article
 
Identifier 0975-0975(Online); 0376-4710(Print)
http://nopr.niscair.res.in/handle/123456789/56967
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-A Vol.60A(04) [April 2021]