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Design, synthesis and evaluation of thiazole based amides for their antitubercular and PknG inhibitory activity

NOPR - NISCAIR Online Periodicals Repository

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Field Value
 
Title Design, synthesis and evaluation of thiazole based amides for their antitubercular and PknG inhibitory activity
 
Creator Sharma, Anindra
 
Subject Peptides
Heterocycles
Benzothiazole
M. tuberculosis
STPK inhibitor
HOBt
DIC
 
Description 624-632
A series of thiazole based amides have been designed and synthesized by solution-phase amide coupling of 2-aminothiazole and its derivatives with naturally occurring aromatic and heteroaromatic acids in excellent yield via DIC/HOBt protocol All the compounds have been evaluated for their antitubercular activity against M. tuberculosis virulent strain M. tuberculosis H37Rv and PknG inhibitory activity in the presence and absence of the inhibitors The compounds display moderate to significant PknG inhibitory activity (9.1-15.6% inhibition at 100 µM) as compared to the standard inhibitors and very moderate in vitro antitubercular activities against M. tuberculosis virulent strain M. tuberculosis H37Rv.
 
Date 2021-04-15T04:49:23Z
2021-04-15T04:49:23Z
2021-04
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/57100
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-B Vol.60B(04) [April 2021]