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Synthesis of pyrimidine linked pyrazole heterocyclics by microwave irradiative cyclocondensation and evaluation of their insecticidal and antibacterial potential

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Title Synthesis of pyrimidine linked pyrazole heterocyclics by microwave irradiative cyclocondensation and evaluation of their insecticidal and antibacterial potential
 
Creator Palaspagar, Kalpana A
Deohate, Pradip P
 
Subject Pyrimidine-pyrazole
Microwave
Insecticidal
Antimicrobial activity
 
Description 611-615
The compounds (4,6-dimethyl-pyrimidin-2-yl)-(5-methyl-2-substituted phenyl/H-pyrazol-3-yl)-amines and (4,6-dimethyl-pyrimidin-2-yl)-(5-methyl-2-substituted benzoyl/isonicotinoyl-pyrazol-3-yl)-amines have been synthesized by microwave irradiative cyclocondensation of N-(4,6-dimethyl-pyrimidin-2-yl)-3-oxo butyramide with substituted hydrazines and acid hydrazides respectively. The required butyramide has been synthesized by the condensation of 2-amino-4,6-dimethyl pyrimidine with ethyl acetoacetate under microwave. The pyrimidine linked pyrazol-3-yl amines on acylation afforded mono/di-acetyl derivatives. Structural elucidation of synthesized compounds has been performed by IR, 1H NMR and mass spectral studies besides chemical transformation and elemental analysis. Title compounds have been screened for their insecticidal activity against Pseudococcidae insects and evaluated for antibacterial potential against some selected microorganisms to establish the structure activity relationship.
 
Date 2021-04-15T04:55:02Z
2021-04-15T04:55:02Z
2021-04
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/57102
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-B Vol.60B(04) [April 2021]