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Silica sulfuric acid catalyzed green synthesis of 1,2- dihydro-1-aryl naphtho[1,2-e][1,3]-oxazin-3-one and 1,2- dihydro-1-methyl naphtho[1,2-e][1,3]-oxazin-3-one as potent antibacterial agents

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Title Silica sulfuric acid catalyzed green synthesis of 1,2- dihydro-1-aryl naphtho[1,2-e][1,3]-oxazin-3-one and 1,2- dihydro-1-methyl naphtho[1,2-e][1,3]-oxazin-3-one as potent antibacterial agents
 
Creator Zhimomi, Betokali K
Imchen, Putusenla
Thurr, Metsütu
Lensayula
Tumtin, Shokip
Phucho, Tovishe
 
Subject Oxazine
Naphthooxazinones
SSA
Solventless
Microwave
 
Description 598-604
A simple, efficient and green method for the preparation of naphthooxazinones employing easily available reagents
2-naphthol, aldehydes, urea and silica sulphuric acid (SSA) as catalyst is reported. The microwave assisted multi component reaction (MCR) procedure provides multiple advantages inclusive of short reaction times, high yields, easy work-up, catalyst recovery and reusability which proves to be environmentally benign. Studies on the antibacterial properties of the synthesized heterocyclic compounds have been done through in vitro methods against gram-positive and gram-negative bacteria.
 
Date 2021-04-15T05:00:29Z
2021-04-15T05:00:29Z
2021-04
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/57104
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-B Vol.60B(04) [April 2021]