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Synthesis and biological evaluation of thiazolidinedione derivatives of chalcones and flavones as antihyperglycemic and antidyslipidemic agents

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Title Synthesis and biological evaluation of thiazolidinedione derivatives of chalcones and flavones as antihyperglycemic and antidyslipidemic agents
 
Creator Satyanarayana, Mavurapu
Shukla, Poonam
Tripathi, Brajendra K
Tiwari, Priti
Srivastava, Arvind K
Pratap, Ram
 
Subject Chalcones
Flavones
Thiazolidinedione
Antihyperglycemic activity
Antidyslipidemic activity
Sucrose loaded model
Streptozotocin model
db/db mice
Glitazones
 
Description 579-588
A series of chalcone and flavone derivatives (6a-d, 9a-f) based on 2,4-thiazolidinedione have been synthesized and evaluated for in vivo antihyperglycemic activity in sucrose loaded (SLM) and streptozotocin (STZ) induced diabetic animal models and also for antidyslipidemic activity in the triton model. Compounds 9d, 9e, and 9f exhibited potent blood glucose-lowering activity in both SLM and STZ models. Compounds 6c, 6d, and 9c, 9e, and 9f showed moderate lipid-lowering activity. The selected most potent compounds 6d and 9e were also studied in db/db mice for both antihyperglycemic and antidyslipidemic activity.
 
Date 2021-04-15T05:06:23Z
2021-04-15T05:06:23Z
2021-04
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/57106
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-B Vol.60B(04) [April 2021]