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<p><strong>Antiurolithiatic activity of <em>trans</em>-cinnamic acid against ethylene glycol induced renal calculi in rats</strong></p>

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Title Statement <p><strong>Antiurolithiatic activity of <em>trans</em>-cinnamic acid against ethylene glycol induced renal calculi in rats</strong></p>
 
Added Entry - Uncontrolled Name Upadhyay, Yagna Y
Airao, Vishal B.
Sharma, Tejas P.
Baravalia, Yogesh K.
Sheth, Navin R.
Parmar, Sachin K.
 
Uncontrolled Index Term Antioxidant, Calcium oxalate, Diuretic, Kidney stone, Nephrolithiasis, Urinary oxalate, Uric acid, Urolithiasis
 
Summary, etc. <p style="text-align: justify;">Urolithiasis is a complex process characterized by supersaturation and retention of salts within the kidney and also a debilitating problem worldwide. Here, we have investigated antiurolithiatic effect of <em>trans</em>-cinnamic acid (<em>t</em>-CA) against ethylene glycol (EG) induced urolithiasis in rats. Urolithiasis was induced in Wistar albino rats using 0.75% v/v EG in drinking water for 28 days. <em>t-</em>CA was administered @200 and 400 mg/kg along with EG for 28 days. Biochemical, urine and histopathological analysis were performed to observe the calcium oxalate (CaC<sub>2</sub>O<sub>4</sub>) deposits and renal tissue damage. The EG group showed significant rise in urine oxalate, calcium, phosphate, and renal tissues oxalates, as compared to normal group. Serum creatinine and uric acid levels were also increased significantly in EG-treated group. Histopathological studies showed marked renal tissue damage and the presence of CaC<sub>2</sub>O<sub>4</sub> crystals. Further, treatment of <em>t</em>-CA significantly ameliorated oxalate, calcium, magnesium, phosphate (urine) and creatinine, uric acid (serum) in EG-induced urolithiasis after 28 days. Moreover, <em>t</em>-CA-treated groups showed reversal of renal tissue damage and reduced level of CaC<sub>2</sub>O<sub>4</sub>. Interestingly, <em>t</em>-CA @400 mg/kg, was more effective in preventing the urolithiasis and regeneration of renal tissues in rats.</p>
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2021-05-29 10:25:29
 
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http://op.niscair.res.in/index.php/IJEB/article/view/50471
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 59, ##issue.no## 05 (2021): IJEB [MAY 2021]
 
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