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<p><strong>Anticancer, antimicrobial, antioxidant and DNA protective potential of mushroom <em>Leucopaxillus gentianeus</em> (Quél.) Kotl.</strong></p>

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Title Statement <p><strong>Anticancer, antimicrobial, antioxidant and DNA protective potential of mushroom <em>Leucopaxillus gentianeus</em> (Quél.) Kotl.</strong></p>
 
Added Entry - Uncontrolled Name Sevindik, Mustafa ; Osmaniye Korkut Ata University, Bahçe Vocational School, Department of Food Processing, Osmaniye, 80500, Turkey
 
Uncontrolled Index Term Bitter false funnelcap, Cytotoxic, Oxidative stress index
 
Summary, etc. <p style="text-align: justify;">Mushrooms are important natural materials used in complementary medicine. In this context, the present study investigates the biological activities and phenolic content of mushroom<em> Leucopaxillus gentianeus</em> (Quél.) Kotl. Methanol (MeOH) and dichloromethane (DCM) extracts of the mushroom was used in the study. Total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were measured with Rel assay kits. DNA protective activity was determined with pBR 322 supercoil DNA. The effects of the extracts on lung cancer A549 cell line were tested to determine the cytotoxic effects. Antimicrobial activities were tested using 9 microorganisms with the modified agar dilution method. The mushroom MeOH and DCM extracts exhibited the highest activity against <em>Candida glabrata, C. albicans</em> and <em>C. krusei</em>. It was also determined that <em>L. gentianeus</em> had a high antioxidant potential. Furthermore, it was identified that DNA protective and cytotoxic activities of the mushroom were also present. Analysis for phenolic contents using HPLC revealed the presence of gallic acid, catechin, epicatechin, cinnamic acid, chlorogenic acid and coumaric acid. Overall results suggest that the mushroom <em>L. gentianeus</em> has considerable pharmacological potential, particularly anticancer, antimicrobial, antioxidant and DNA protective action.</p>
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2021-05-29 10:25:29
 
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http://op.niscair.res.in/index.php/IJEB/article/view/50501
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 59, ##issue.no## 05 (2021): IJEB [MAY 2021]
 
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