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<em>In vitro</em> and <em>in silico</em> studies on the biochemistry and anti-cancer activity of phytochemicals from <em>Plumbago zeylanica</em>

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Title Statement <em>In vitro</em> and <em>in silico</em> studies on the biochemistry and anti-cancer activity of phytochemicals from <em>Plumbago zeylanica</em>
 
Added Entry - Uncontrolled Name Jenifer, D Roselin
Malathy, BR
SS, Ariya
 
Uncontrolled Index Term Column chromatography; Matrix metalloproteins; Oral squamous cell carcinoma; Phenol, 2,4, bis (1,1-dimethyl ethyl); Plumbago zeylanica; Secondary metabolites
 
Summary, etc. <em>Plumbago zeylanica</em> is an effective medicinal plant and a potent herb for various diseases. The leaves of <em>P. zeylanica</em> were subjected to crude extraction using Ethyl acetate. Chromatographic analysis of the crude extracts of <em>P. zeylanica</em> were studied in thin layer chromatography on a silica gel matrix. Further the extracts were purified in column chromatography and the fractions were eluted in Ethyl acetate, Chloroform solvent system. The molecules eluted in the fractions were checked in UV-spectroscopy and further characterised by GC-MS analysis. Phenol, 2,4, bis (1,1-dimethyl ethyl)-(7311) highlighted from the chromatographic studies was studied for in silico anticancer effect on matrix metalloproteins, whose dysfunction cause oral squamous cell carcinoma.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2021-06-01 14:23:30
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJBB/article/view/26232
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); IJBB Vol. 58 (3) [June 2021]
 
Language Note en