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Synthesis and biological evaluation of a series of novel benzofuran-2-carboxylate 1,2,3-triazoles

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Title Synthesis and biological evaluation of a series of novel benzofuran-2-carboxylate 1,2,3-triazoles
 
Creator Bhaskar, K
Yadav, J S
 
Subject 1,2,3-Triazoles
benzofuran-2-carboxylate
Green chemistry
Antimicrobial activity
 
Description 767-774
A facile and efficient synthetic route has been developed to substituted benzofuran-2-carboxylate 1,2,3-triazoles for the first time by reacting prop-2-yn-1-yl benzofuran-2-carboxylate with a variety of substituted aryl/benzyl azides in DMF/H2O system employing standard click reaction. This new method has the lead of good yields, inexpensive reagents, easily available, easy work-up, mild reaction conditions, and environmentally friendly reaction conditions. All these compounds have been characterized by modern spectral techniques such as IR, 1H NMR, and mass spectroscopy, etc. Evaluation of synthesized compounds for antimicrobial activity against specific bacterial strains like Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa along with antifungal activity against Aspergillus niger and Sclerotium rolfsii have been carried out.
 
Date 2021-06-25T07:19:46Z
2021-06-25T07:19:46Z
2021-05
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/57581
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-B Vol.60B(05) [May 2021]