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Dibenzofurans from Cladonia corniculata Ahti and Kashiw inhibit key enzymes involved in inflammation and gout: An in vitro approach

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Title Dibenzofurans from Cladonia corniculata Ahti and Kashiw inhibit key enzymes involved in inflammation and gout: An in vitro approach
 
Creator Tatipamula, Vamsi Krishna
Tatipamula, Vinay Bharadwaj
 
Subject 5-Lipoxygenase
Cladonia corniculata
Cyclooxygenase
Lichen
Xanthine oxidase
 
Description 715-719
The usage of natural sources like lichen extracts and their metabolites as anti-inflammatory agents is well known for ages. Based on the data of the folklore and documented books, researchers tested lichens and their products for anti-inflammatory properties and they identified many therapeutic agents used to diagnosis acute and chronic inflammation with lesser side effects. In this study, we aimed to examine the acetone extract of Cladonia corniculata(AE)and its metabolites for in vitro anti-inflammatory and anti-gout effects. Through chemical investigation, we have successfully isolated and identified three known dibenzofurans, namely alectosarmentin 1, porphyrilic acid 2, and strepsilin 3 from the AE. All isolated dibenzofurans1-3 showed prominent inhibition of cyclooxygenase enzymes, whereas compounds 1 and 2 exhibited noticeable inhibition of 5-lipoxygenase enzyme. Only compound 2 showed significant inhibition of xanthine oxidase enzyme with an IC50 value of 80.17±0.66 µg/mL, while standard drug allopurinol with 9.10±0.64 µg/mL. The results indicate that C. corniculatacan be a favourable natural source for the treatment of inflammation and gout and these actions are linked to the natural active dibenzofurans1-3.
 
Date 2021-06-25T07:47:52Z
2021-06-25T07:47:52Z
2021-05
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/57588
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-B Vol.60B(05) [May 2021]