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<p>Synthesis, characterization and evaluation of new thiazole derivatives as anthelmintic agents</p><br />

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Title Statement <p>Synthesis, characterization and evaluation of new thiazole derivatives as anthelmintic agents</p><br />
 
Added Entry - Uncontrolled Name Sai Krishna Guduru, D Kumara Swamy ; Vaagdevi college of pharmacy affiliated to Kakathiya university
Guduru, Sai Krishna; Medicinal Chemistry Research Division, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda 506 001, India
Sirisha, K ; Medicinal Chemistry Research Division, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda 506 001, India
Santhoshi, K Sai; Medicinal Chemistry Research Division, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda 506 001, India
 
Uncontrolled Index Term Anthelmintic activity, Pheretima postuma, molecular docking, thiazole derivatives, β-tubulin protein
 
Summary, etc. <p>A series of 2-amino substituted 4-phenyl thiazole derivatives has been synthesized by the conventional method. The thiazole derivatives have been synthesized by three steps. The obtained five derivatives have been purified by recrystallization process by using methanol as solvent and column chromatography [IVd Compound] and have been characterized by melting point, TLC, FTIR, <sup>1</sup>H NMR and mass spectral data. All the five derivatives have been evaluated using <em>in silico</em> studies by using different softwares (Lipinski’s Rule of 5, OSIRIS molecular property explorer, Molsoft molecular property explorer, PASS and docking studies). These compounds have then been evaluated for anthelmintic activity against Indian adult earth worms (<em>Pheretima postuma</em>). All the compounds show significant anthelmintic activity. The compound IVc and IVe are shown to be potent compounds when compared with the standard drug (Mebendazole). Molecular docking studies have guided and prove the biological activity of the sythesised compounds against beta tubulin protein (1OJ0).</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-06-29 10:54:31
 
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http://op.niscair.res.in/index.php/IJCB/article/view/29285
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 4 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
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