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<p>Synthesis and biological evaluation of thiazolidinedione derivatives of chalcones and flavones as antihyperglycemic and antidyslipidemic agents</p><p> </p>

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Title Statement <p>Synthesis and biological evaluation of thiazolidinedione derivatives of chalcones and flavones as antihyperglycemic and antidyslipidemic agents</p><p> </p>
 
Added Entry - Uncontrolled Name Satyanarayana, Mavurapu ; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226 031, India
Shukla, Poonam ; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226 031, India
Pratap, Ram ; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226 031, India
Tripathi, Brajendra K; Division of Biochemistry CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226 031, India
Srivastava, Arvind K; Division of Biochemistry CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226 031, India
Tiwari, Priti ; Division of Biochemistry CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226 031, India
 
Uncontrolled Index Term Chalcones, flavones, thiazolidinedione, antihyperglycemic activity, antidyslipidemic activity, sucrose loaded model, streptozotocin model, db/db mice, glitazones
 
Summary, etc. <p>A series of chalcone and flavone derivatives (<strong>6a-d, 9a-f</strong>) based on 2,4-thiazolidinedione have been synthesized and evaluated for <em>in vivo</em> antihyperglycemic activity in sucrose loaded (SLM) and streptozotocin (STZ) induced diabetic animal models and also for antidyslipidemic activity in the triton model. Compounds <strong>9d</strong>, <strong>9e</strong>, and <strong>9f</strong> exhibited potent blood glucose-lowering activity in both SLM and STZ models. Compounds <strong>6c</strong>, <strong>6d</strong>, and <strong>9c</strong>, <strong>9e</strong>, and <strong>9f</strong> showed moderate lipid-lowering activity. The selected most potent compounds <strong>6d</strong> and <strong>9e</strong> were also studied in <em>db/db</em> mice for both antihyperglycemic and antidyslipidemic activity.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-06-29 10:54:31
 
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http://op.niscair.res.in/index.php/IJCB/article/view/38425
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 4 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/38425/465519565
http://op.niscair.res.in/index.php/IJCB/article/download/38425/465519665
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http://op.niscair.res.in/index.php/IJCB/article/download/38425/465519867
http://op.niscair.res.in/index.php/IJCB/article/download/38425/465520348
http://op.niscair.res.in/index.php/IJCB/article/download/38425/465520823
http://op.niscair.res.in/index.php/IJCB/article/download/38425/465522053
 
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