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<p>Design, synthesis and evaluation of thiazole based amides for their <br /> antitubercular and PknG inhibitory activity</p><p> </p>

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Title Statement <p>Design, synthesis and evaluation of thiazole based amides for their <br /> antitubercular and PknG inhibitory activity</p><p> </p>
 
Added Entry - Uncontrolled Name Sharma, Anindra ; Department of Chemistry, A.P.S.M College, Barauni, Begusarai 851 112, India (A Constituent Unit of Lalit Narayan Mithila University, Darbhanga)
CSIR
 
Uncontrolled Index Term Peptides, heterocycles, benzothiazole, M. tuberculosis, STPK inhibitor, HOBt, DIC
 
Summary, etc. <p>A series of thiazole based amides have been designed and synthesized by solution-phase amide coupling of 2-aminothiazole and its derivatives with naturally occurring aromatic and heteroaromatic acids in excellent yield <em>via</em> DIC/HOBt protocol All the compounds have been evaluated for their antitubercular activity against<em> M. tuberculosis</em> virulent strain<em> M. tuberculosis H37Rv </em>and PknG inhibitory activity in the presence and absence of the inhibitors The compounds display moderate to significant PknG inhibitory activity (9.1-15.6% inhibition at 100 µM) as compared to the standard inhibitors and very moderate <em>in vitro</em> antitubercular activities against <em>M. tuberculosis</em> virulent strain<em> M. tuberculosis H37Rv</em>.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-06-29 10:54:31
 
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http://op.niscair.res.in/index.php/IJCB/article/view/37131
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 4 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/37131/465515104
http://op.niscair.res.in/index.php/IJCB/article/download/37131/465517549
http://op.niscair.res.in/index.php/IJCB/article/download/37131/465517550
 
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