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<p>Dibenzofurans from <em>Cladonia corniculata</em> Ahti and Kashiw inhibit key enzymes involved in inflammation and gout: An <em>in vitro</em> approach</p><p> </p>

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Title Statement <p>Dibenzofurans from <em>Cladonia corniculata</em> Ahti and Kashiw inhibit key enzymes involved in inflammation and gout: An <em>in vitro</em> approach</p><p> </p>
 
Added Entry - Uncontrolled Name Tatipamula, Vinay Bharadwaj; Institute of Research and Development, Duy Tan University, Quang Trung, Da Nang 550000, Vietnam, Faculty of Pharmacy, Duy Tan University, Quang Trung, Da Nang 550000, Vietnam
Tatipamula, Vamsi Krishna; Gudlavalleru Engineering College, Sheshadri Rao Knowledge Village, Gudlavalleru, Vijayawada 521 356, India
 
Uncontrolled Index Term 5-Lipoxygenase, Cladonia corniculata, cyclooxygenase, lichen, xanthine oxidase
 
Summary, etc. <p class="Abstract">The usage of natural sources like lichen extracts and their metabolites as anti-inflammatory agents is well known for ages. Based on the data of the folklore and documented books, researchers tested lichens and their products for anti-inflammatory properties and they identified many therapeutic agents used to diagnosis acute and chronic inflammation with lesser side effects. In this study, we aimed to examine the acetone extract of <em>Cladonia corniculata</em><strong>(AE)</strong>and its metabolites for <em>in vitro</em> anti-inflammatory and anti-gout effects. Through chemical investigation, we have successfully isolated and identified three known dibenzofurans, namely alectosarmentin <strong>1</strong>, porphyrilic acid <strong>2</strong>, and strepsilin <strong>3</strong> from the <strong>AE</strong>. All isolated dibenzofurans<strong>1-3</strong> showed prominent inhibition of cyclooxygenase enzymes, whereas compounds <strong>1 </strong>and <strong>2</strong> exhibited noticeable inhibition of 5-lipoxygenase enzyme. Only compound <strong>2</strong> showed significant inhibition of xanthine oxidase enzyme with an IC<sub>50</sub> value of 80.17±0.66 µg/mL, while standard drug allopurinol with 9.10±0.64 µg/mL. The results indicate that <em>C. corniculata</em>can be a favourable natural source for the treatment of inflammation and gout and these actions are linked to the natural active dibenzofurans<strong>1-3</strong>.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-06-30 14:47:49
 
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http://op.niscair.res.in/index.php/IJCB/article/view/38966
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 5 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/38966/465521208
http://op.niscair.res.in/index.php/IJCB/article/download/38966/465521209
 
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