Record Details

<p>Voltammetric study of itraconazole an antifungal drug at glassy carbon electrode in acidic medium: A simple plus cost-effective detection method</p><p> </p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p>Voltammetric study of itraconazole an antifungal drug at glassy carbon electrode in acidic medium: A simple plus cost-effective detection method</p><p> </p>
 
Added Entry - Uncontrolled Name Jakhar, Varsha ; Electrochemical Sensor Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur 302 004, India
Sharma, D. K. ; Electrochemical Sensor Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur 302 004, India
CSIR, New Delhi
 
Uncontrolled Index Term Itraconazole, antifungal drug, anodic stripping voltammetry, glassy carbon electrode (GCE), BR buffer (pH 3.0)
 
Summary, etc. <p class="Abstract">In this study, the electro-oxidative behaviour and determination of itraconazole at a glassy carbon electrode have been investigated using cyclic voltammetry, differential pulse anodic stripping voltammetry (DPASV), and square wave anodic stripping voltammetric (SWASV) techniques, under different experimental conditions. The voltammetric peak current for the oxidation of itraconazole has been analyzed at different <em>p</em>H, scan rate and concentrations. The voltammograms have exhibited irreversible oxidation of ITRA in B.R. buffer of <em>p</em>H 3.0. The oxidation of itraconazole gives a well-defined irreversible peak at glassy carbon electrode <em>vs.</em> Ag/AgCl as reference electrode. The oxidation process is adsorption controlled. A linear response has been obtained between 26.7×10<sup>–6</sup> to 152.8×10<sup>–6</sup> M in non-aqueous media for all the techniques. The analyzed square wave anodic voltammetric and differential pulse anodic stripping voltammetric methods show limit of detection at 27.28 µM and 65.16 µM respectively. Ultimately, the proposed validated method has been effectively applied for the determination of the antifungal drug which is commercially available in solid form.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-06-30 14:47:49
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJCB/article/view/39544
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 5 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/39544/465523198
http://op.niscair.res.in/index.php/IJCB/article/download/39544/465523199
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2015. The Council of Scientific &amp; Industrial Research, New Delhi.