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<p><strong>Effect of 17α-methyltestosterone (MT) on osmoregulatory responses and apoptosis in genetically improved farmed tilapia (GIFT), <em>Oreochromis niloticus</em> (L.)</strong></p>

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Title Statement <p><strong>Effect of 17α-methyltestosterone (MT) on osmoregulatory responses and apoptosis in genetically improved farmed tilapia (GIFT), <em>Oreochromis niloticus</em> (L.)</strong></p>
 
Added Entry - Uncontrolled Name Zheng, Yao ; Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences/Fishery Eco-Evironment Monitoring Center of Lower Reaches of Yangtze River/Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture, Wuxi 214081, China Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China
Bing, Xuwen ; Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences/Fishery Eco-Evironment Monitoring Center of Lower Reaches of Yangtze River/Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture, Wuxi 214081, China Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China
Hu, Gengdong ; Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences/Fishery Eco-Evironment Monitoring Center of Lower Reaches of Yangtze River/Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture, Wuxi 214081, China
Song, Chao ; Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences/Fishery Eco-Evironment Monitoring Center of Lower Reaches of Yangtze River/Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture, Wuxi 214081, China
Qiu, Liping ; Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences/Fishery Eco-Evironment Monitoring Center of Lower Reaches of Yangtze River/Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture, Wuxi 214081, China
Meng, Shunlong ; Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences/Fishery Eco-Evironment Monitoring Center of Lower Reaches of Yangtze River/Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture, Wuxi 214081, China
Fan, Limin ; Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences/Fishery Eco-Evironment Monitoring Center of Lower Reaches of Yangtze River/Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture, Wuxi 214081, China
Dan-dan, Li ; Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences/Fishery Eco-Evironment Monitoring Center of Lower Reaches of Yangtze River/Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture, Wuxi 214081, China
Chen, Jiazhang ; Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences/Fishery Eco-Evironment Monitoring Center of Lower Reaches of Yangtze River/Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture, Wuxi 214081, China Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China
 
Uncontrolled Index Term Aquatic pollution, Fish farming, Masculinisation, Nile tilapia
 
Summary, etc. <p style="text-align: justify;">Androgenic compounds can affect osmoregulatory response and apoptosis in fish. In the present study, we exposed genetically improved farmed tilapia (GIFT) <em>Oreochromis niloticus</em> (L.) to 17α-methyltestosterone (MT, 0.5 and 5 mg/L) for 7, 14 and 21 days for understanding the phenomenon. The activities of Na<sup>+</sup>/K<sup>+</sup> ATPase (NKA) and Ca<sup>2+</sup>/Mg<sup>2+</sup> ATPase (CMA) were measured in the gill, kidney and intestine to evaluate the change in osmoregulation of GIFT, and genotoxicity was also detected. Results showed that organic NKA were significantly decreased in 5 mg/L MT exposure groups. The intestine NKA was significantly increased (0.5 mg/L MT). MT exposures increased the CMA of kidney and intestine (0.5 mg/L), together with gill CMA (5 mg/L MT). The results of genotoxicity assay showed gill <em>atp</em>1<em>a</em>1<em>a</em> and <em>nkcc</em>2 transcripts significantly increased, while intestine <em>atp</em>1<em>a</em>1<em>a</em> and<em> fxyd</em>7<em> </em>transcripts revealed significant increases for MT exposure groups. Caspases proteins demonstrated significant increases at 7<sup>th</sup> and 21<sup>st</sup> day, and their transcripts were enhanced in 0.5 mg/L MT exposure groups. The results have evidently demonstrated that chronic exposure of MT could result in organic osmoregulatory response and hepatic apoptosis in GIFT <em>O</em>. <em>niloticus</em>.</p>
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2021-06-30 15:40:35
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJEB/article/view/51859
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 59, ##issue.no## 06 (2021): IJEB [JUNE 2021]
 
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