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<p>Synthesis and crystal structures of 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone (L) and its metal complexes: Anticancer activity of [Cu(L)(OAc)]<span style="white-space: pre;"> </span></p>

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Title Statement <p>Synthesis and crystal structures of 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone (L) and its metal complexes: Anticancer activity of [Cu(L)(OAc)]<span style="white-space: pre;"> </span></p>
 
Added Entry - Uncontrolled Name Ghosh, Rajarshi ; The University of Burdwan
Biswas, Chinmoy ; Department of Chemistry, The University of Burdwan, Burdwan 713 104, India
Chatterjee, Arnab ; Department of Chemistry, The University of Burdwan, Burdwan 713 104, India
Sreekumar, Sreelekshmi ; Biological Materials Laboratory, CSIR-Central Leather Research Institute, Chennai 600 020, India
Kiran, Manikantan Syamala; Biological Materials Laboratory, CSIR-Central Leather Research Institute, Chennai 600 020, India
 
Uncontrolled Index Term Cu(II), Zn(II), Thiosemicarbazone, X-ray structure, Anticancer activity
 
Summary, etc. <p style="text-align: justify;">Synthesis and structural characterization of N(4)-substituted 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone (<strong>L</strong>) and its two metal complexes [Cu(L)(OAc)] (<strong>1</strong>) and [ZnL(OAc)]<sub>2 </sub>(<strong>2</strong>)<em> </em>are reported. Between the two complexes <strong>1 </strong>is found to have good anticancer activity against Human lung cancer cell line (A549). Fluorescence microscopy finds the formation of reactive oxygen species on treatment of the cancer cells with <strong>1</strong>. The IC<sub>50</sub> value of the complex is measured as 0.72 mM which is lower than that of cisplatin against A549.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2021-07-01 11:17:45
 
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http://op.niscair.res.in/index.php/IJCA/article/view/43196
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 60, ##issue.no## 4 (2021): INDIAN JOURNAL OF CHEMISTRY- SECTION A
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/43196/465537194
http://op.niscair.res.in/index.php/IJCA/article/download/43196/465537195
http://op.niscair.res.in/index.php/IJCA/article/download/43196/465537196
http://op.niscair.res.in/index.php/IJCA/article/download/43196/465537197
http://op.niscair.res.in/index.php/IJCA/article/download/43196/465537198
http://op.niscair.res.in/index.php/IJCA/article/download/43196/465537199
http://op.niscair.res.in/index.php/IJCA/article/download/43196/465537200
 
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