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<p style="text-align: justify;">Synthesis, spectral elucidation, antibacterial, antioxidant and DNA studies of ONNO tetradentate Schiff base metal(II) complexes derived from Benzene-1,4-dicarboxaldehyde</p>

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Title Statement <p style="text-align: justify;">Synthesis, spectral elucidation, antibacterial, antioxidant and DNA studies of ONNO tetradentate Schiff base metal(II) complexes derived from Benzene-1,4-dicarboxaldehyde</p>
 
Added Entry - Uncontrolled Name savitha, kumarasamy ; Department of Chemistry, Kandaswami Kandar’s College, ParamathiVelur (TK), Tamil Nadu 638 182, India
Vedanayaki, Subramaniam ; Department of Chemistry, Kandaswami Kandar’s College, ParamathiVelur (TK), Tamil Nadu 638 182, India
 
Uncontrolled Index Term structural inorganic chemistry, bio-inorganic chemistry
Schiff bases, Square planar, Antimicrobial, Antioxidant, DNA studies, Antitumour activity
 
Summary, etc. <p style="text-align: justify;">The new dibasic tetradentate (ONNO) Schiff base ligands (L<sub>1</sub>and L<sub>2</sub>) have been synthesized by the reaction of terephthalaldehyde with 2-amino 4-chlorophenol and X (where, X=2-amino 4-ethylphenol, 2-aminophenol) in 1:1:1 molar ratio. The macrocyclic binuclear Co(II), Ni(II) and Cu((II) metal complexes are prepared in ligand to metal ratio 2:2. The elements, metal structure and binding sites of Schiff bases and its complexes are established by diverse studies like elemental, molar conductance, UV, magnetic moment, FT-IR, H<sup>1</sup> and C<sup>13</sup> NMR, ESI-mass, ESR, thermal and powder-XRD. The spectral studies reveal that the ligands are tetradentate and its metal complexes possess a square planar geometry. All the compounds are screened for antibacterial, antioxidant and DNA cleavage and the results show high activity for metal complexes than the ligand. The DNA binding studies of Cu(II) complexes were measured by electronic absorption method. <em>In vitro</em> cytotoxicity assay of Cu(II) complexes have been tested for their tumour inhibiting potential against MCF-7 human breast cancer cell by using MTT method<strong>.</strong></p><br />
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2021-07-01 12:48:51
 
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http://op.niscair.res.in/index.php/IJCA/article/view/30505
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 60, ##issue.no## 5 (2021): INDIAN JOURNAL OF CHEMISTRY- SECTION A
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/30505/465493747
http://op.niscair.res.in/index.php/IJCA/article/download/30505/465494004
 
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