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<p><span>The potential anticancer activities of platinum(II) complexes with tridentate N'N'N' pincer ligands</span></p>

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Title Statement <p><span>The potential anticancer activities of platinum(II) complexes with tridentate N'N'N' pincer ligands</span></p>
 
Added Entry - Uncontrolled Name Lasri, Jamal ; Department of Chemistry, Rabigh College of Science and Arts, King Abdulaziz University, Jeddah, Saudi Arabia
Aly, Magda M; Department of Biology, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
Eltayeb, Naser E; Department of Chemistry, Rabigh College of Science and Arts, P.O. Box 344, King Abdulaziz University, Jeddah, Saudi Arabia
Alamri, Mona A; Department of Chemistry, College of Science and Arts, Qassim University, Buraydah 51452, Saudi Arabia
Babgi, Bandar A; Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
Hussien, Mostafa A; Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
None
 
Uncontrolled Index Term Synthetic and structural inorganic chemistry; Bio-inorganic chemistry; theoretical & quantum chemistry; spectroscopy
Platinum(II) complexes, Pincer ligands, Antimicrobial, Anticancer, DNA-binding, Molecular docking
 
Summary, etc. <p style="text-align: justify;">Treatment of <em>cis/trans</em>-[PtCl<sub>2</sub>(N≡CR)<sub>2</sub>] <strong>1 </strong>(R = CH<sub>3</sub> (<strong>1a</strong>), C<sub>2</sub>H<sub>5</sub> (<strong>1b</strong>), C<sub>6</sub>H<sub>5</sub> (<strong>1c</strong>), CH<sub>2</sub>C<sub>6</sub>H<sub>4</sub>(<em>p</em>-CH<sub>3</sub>) (<strong>1d</strong>)) with 1,3-diiminoisoindoline <strong>2 </strong>gives access to the corresponding symmetrical (1,3,5,7,9-pentaazanona-1,3,6,8-tetraenato) platinum(II) complexes [PtCl{<span style="text-decoration: underline;">N</span>H=C(R)N=C(C<sub>6</sub>H<sub>4</sub>)<span style="text-decoration: underline;">N</span>C=NC(R)=<span style="text-decoration: underline;">N</span>H}] <strong>3a-d</strong>, in good yields (65–77%). The compounds <strong>3a-d </strong>have been characterized by IR, <sup>1</sup>H, <sup>13</sup>C and DEPT-135 NMR spectroscopies, ESI-MS and elemental analyses. GIAO/DFT studies have been performed to confirm the molecular structure of the platinum(II)-pincer <strong>3d</strong> by comparing the experimental and theoretical <sup>1</sup>H and <sup>13</sup>C NMR chemical shifts, and it has shown good correlations between experimental and calculated chemical shifts for proton and carbon with correlation coefficients of 0.9947 and 0.9968, respectively. Molecular electrostatic potential is used to investigate the nucleophilic or electrophilic regions in the molecule <strong>3d</strong>. The antimicrobial activities of compounds <strong>3a-d</strong> are determined against different bacterial pathogens and yeasts. No toxicity is recorded against <em>Artemia saline</em> as a test organism for <strong>3a-c</strong>, while moderate toxicity is found for <strong>3d</strong> at 0.62 µM. Comparable antitumor activities are found for <strong>3a-d </strong>against human colon HCT116 and human breast (MCF-7) cancer cell lines. The complexes <strong>3a-d</strong> have shown good binding affinities to ct-DNA in the range of 6.00´10<sup>5</sup> to 8.33´10<sup>5</sup> and the conducted molecular docking studies suggest an intercalation mode of binding with DNA by the isoindole fragment of the ligands. Overall, this class of tridentate ligands have shown good potential in designing platinum(II) complexes with promising biological and anticancer activities. Moreover, the presence of the side chains on the ligands provides great design flexibility by introducing some chemical and/or physical characteristics.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2021-07-01 11:17:45
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJCA/article/view/33532
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 60, ##issue.no## 4 (2021): INDIAN JOURNAL OF CHEMISTRY- SECTION A
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/33532/0
http://op.niscair.res.in/index.php/IJCA/article/download/33532/465503686
http://op.niscair.res.in/index.php/IJCA/article/download/33532/465503689
http://op.niscair.res.in/index.php/IJCA/article/download/33532/465503691
http://op.niscair.res.in/index.php/IJCA/article/download/33532/465503692
 
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