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Effect of 17α-methyltestosterone (MT) on osmoregulatory responses and apoptosis in genetically improved farmed tilapia (GIFT), Oreochromis niloticus (L.)

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Title Effect of 17α-methyltestosterone (MT) on osmoregulatory responses and apoptosis in genetically improved farmed tilapia (GIFT), Oreochromis niloticus (L.)
 
Creator Zheng, Yao
Bing, Xuwen
Hu, Gengdong
Song, Chao
Qiu, Liping
Meng, Shunlong
Fan, Limin
Dan-dan, Li
Chen, Jiazhang
 
Subject Aquatic pollution
Masculinisation
Nile tilapia
Fish farming
 
Description 361-368
Androgenic compounds can affect osmoregulatory response and apoptosis in fish. In the present study, we exposed genetically improved farmed tilapia (GIFT) Oreochromis niloticus (L.) to 17α-methyltestosterone (MT, 0.5 and 5 mg/L) for 7, 14 and 21 days for understanding the phenomenon. The activities of Na+/K+ ATPase (NKA) and Ca2+/Mg2+ ATPase (CMA) were measured in the gill, kidney and intestine to evaluate the change in osmoregulation of GIFT, and genotoxicity was also detected. Results showed that organic NKA were significantly decreased in 5 mg/L MT exposure groups. The intestine NKA was significantly increased (0.5 mg/L MT). MT exposures increased the CMA of kidney and intestine (0.5 mg/L), together with gill CMA (5 mg/L MT). The results of genotoxicity assay showed gill atp1a1a and nkcc2 transcripts significantly increased, while intestine atp1a1a and fxyd7 transcripts revealed significant increases for MT exposure groups. Caspases proteins demonstrated significant increases at 7th and 21st day, and their transcripts were enhanced in 0.5 mg/L MT exposure groups. The results have evidently demonstrated that chronic exposure of MT could result in organic osmoregulatory response and hepatic apoptosis in GIFT O. niloticus.
 
Date 2021-07-06T05:21:20Z
2021-07-06T05:21:20Z
2021-06
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/57637
 
Language en
 
Publisher CSIR-NIScPR, India
 
Source IJEB Vol.59(06) [June 2021]