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Design, synthesis and antibacterial activity of 9-aryl-6-(2-naphthyl) [1,2,4]triazolo[4,3-a][1,8]naphthyridines

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Title Design, synthesis and antibacterial activity of 9-aryl-6-(2-naphthyl) [1,2,4]triazolo[4,3-a][1,8]naphthyridines
 
Creator Challa, Pradeep Kumar
Ega, Jagadeesh Kumar
Siddoju, Kavitha
 
Subject 1,8-Naphthyridine
1,2,4-triazole
SiO2-FeCl3
microwave irradiation
antibacterial activity
 
Description 901-905
A concise and highly efficient procedure has been described for the synthesis of 9-aryl-6-(2-naphthyl)[1,2,4]
triazolo[4,3-a][1,8]naphthyridines8 by the oxidation of the corresponding aryl aldehyde1-[3-(2-naphthyl) [1,8]naphthyridin-
2-yl]hydrazones 7 using silica gel supported ferric chloride (SiO2-FeCl3) in solvent-free conditions under microwave
irradiation. The desired products are obtained in very good yields and in a state of high purity. The structure of compounds
3-8 have been confirmed by their spectroscopic (IR, 1H NMR and MS) and analytical data. The compounds 8a-j have been
screened for their antibacterial activity
 
Date 2021-07-20T04:46:47Z
2021-07-20T04:46:47Z
2021-06
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/57733
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC-B Vol.60B(06) [June 2021]