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Synthesis, characterization, cytotoxicity evaluation and physicochemical properties of some novel N4-substituted aminobenzenesulfonamides

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Title Synthesis, characterization, cytotoxicity evaluation and physicochemical properties of some novel N4-substituted aminobenzenesulfonamides
 
Creator Durgun, Mustafa
Zengin, Gulay
Zengin, Huseyin
Koyuncu, Ismail
Turkoglu, Seda
Sonmez, Hasan
Kuru, Ali
 
Subject Synthesis
N4-substituted aminobenzenesulfonamides
cytotoxicity
photoluminescence
physicochemical properties
 
Description 888-900
Several N4-substituted aminobenzenesulfonamides derivatives have been synthesized and structural analyses have been carried out using FT-IR, UV-Vis, 1H and 13C NMR, LC-MS-MS and elemental analyses. Photoluminescence and physicochemical properties have also been conducted. Two 4-aminobenzenesulfonamides have been treated with 2-bromopropionyl bromide in pyridine to give their respective bromo substituted aminobenzenesulfonamides as intermediates. Subsequent reactions with morpholino-, thiomorpholino- and piperazine amines have yielded novel aminobenzenesulfonamide derivatives. As it is well known that CA IX and CA XII enzymes play an active role in attacking various cancerous conditions, studies presented in this study target these enzymes with in vitro cytotoxicity studies being performed on the compounds synthesized. The target compounds have been found to be active against some cancerous cells, with mimimal effects on normal cells. The physicochemical data reveal interesting synergistic effects controlling cytotoxicities, where the lipophilicity and polarity combinations play important roles on the eventual observed cytotoxicities. Further, the electronegativity and availability of the electrons of the heteroatoms of the synthesized compounds appear to have an effect on cancer cell cytotoxicities.
 
Date 2021-07-20T04:50:53Z
2021-07-20T04:50:53Z
2021-06
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/57734
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC-B Vol.60B(06) [June 2021]