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Surface modifications of biodegradable polymeric nanoparticles and their characterization by advanced electron microscopy techniques

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Title Statement Surface modifications of biodegradable polymeric nanoparticles and their characterization by advanced electron microscopy techniques
 
Added Entry - Uncontrolled Name Kulshrestha, Ritu
Singh, Amit
Kumar, Pawan
Mishra, AK
Dinda, AK
 
Uncontrolled Index Term Electron microscopic characteristics; Polymeric nanoparticles; Surface modifications
 
Summary, etc. Polymeric nanoparticles have been the focus for nanocarrier preparation in numerous biomedical applications such as cancer treatment, disease diagnosis, vaccination, in the last two decades. They have been variably surface modified using copolymers, Polyethylene glycol (PEG), dextran, cyclodextrin, cytokines, small molecules to improve their efficiency and efficacy. The resulting nano-formulations include polymer-protein conjugate, polymeric micelle, polymer-small molecule conjugate, dendrimer, polymeric vesicles, nano-hybrids, hydrogels etc. These may have intrinsic immunogenicity and require accurate characterization in order to improve their pharmacological targeting, pharmacokinetic profiles and to reduce adverse reactions. Therefore, we have reviewed the polymeric nanoparticles and the electron microscopy techniques available for their characterization in the context of their surface modifications and functionalization.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2021-07-27 16:47:04
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJBB/article/view/51295
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); IJBB Vol. 58 (4) [August 2021]
 
Language Note en