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A study of acute dermal toxicity of Artemisia herba-alba Asso essential oils

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Title A study of acute dermal toxicity of Artemisia herba-alba Asso essential oils
 
Creator Asma, Boukhennoufa
Boumediene, Meddah
Aicha, Tir Touil Meddah
 
Subject Acute skin toxicity
Artemisia herba-alba Asso
Essential oils
LD50
 
Description 225-229
Medicinal plants constitute a huge reserve of many therapeutic virtues recognized by their powerful effects since the
dawn of time. Our research focused on the study of acute skin toxicity (AST) of Artemisia herba-alba Asso (Aha) essential
oils, obtained by hydrodistillation. AST has been evaluated, using rats of the species Rattus norvegicus with reference to a
method proposed by the organisation for economic co-operation and development (OECD) guideline. Biochemical
parameters, alanine aminotransferase, aspartate aminotransférase, total bilirubin, direct bilirubin, and creatinine were
measured in whole blood after animal sacrifices. In parallel, the histological liver and kidney sections were analyzed. The
Lethal dose50 (LD50) value was found greater than 5000 mg/kg. In addition, the biochemical markers of the tested rats did
not change during the experiment compared to the control group. No tissue damage has been detected. A. herba alba Asso
essential oil was considered non-dangerous, which can be used to heal against all benign or severe illnesses.
 
Date 2021-07-28T05:00:08Z
2021-07-28T05:00:08Z
2021-06
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscair.res.in/handle/123456789/57757
 
Language en
 
Relation Int. cl. (2015.01)- A61K 36/00, A61K 36/28
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.12(2) [June 2021]