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Novel anticancer drug delivery system based on zeolite encapsulating Hamelia patens leaf and flower extracts

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Title Novel anticancer drug delivery system based on zeolite encapsulating Hamelia patens leaf and flower extracts
 
Creator El-Sawi, Salma A
Motawae, Hemaia M
Abdel kawy, Mostafa A
Fekry, Mostafa I
Youssef, Hanan F
 
Subject Anthocyanins
Antiproliferative
Chromosome aberrations
Flavonoids
Hamelia patens
Zeolite
 
Description 181-194
Nanotechnology had placed an impact in improving the antiproliferative activity of crude leaf (CL) and flower (CF)
extracts of Hamelia patens on the liver (HEPG2) and breast (MCF7) carcinoma cell lines, after their encapsulation onto
zeolite (ZSM-5) nanopores, which acts as a drug delivery system (DDS). The cytotoxicity of the new formulas showed
remarkable improvement in the activities on HEPG2. CL had low activity on HEPG2, at the tested concentrations, but the
ZSM-5 loaded one (CLZ) showed enhanced action with IC50=42 μg/mL. Also, the cytotoxicity of CF improved after Zeolite
incorporation, where the IC50 has been changed from 48 μg/mL for CF to 25 μg/mL for CFZ. Moreover, the polar fraction of
leaves extracted by methanol (Me.L) showed improvement on the cytotoxicity on MCF7 for zeolite loaded formula (Me.Z)
(IC50 had changed from 65 to 44.4 μg/mL). Quantitative estimations for polyphenolic contents as well as the phenolic
profiles for CF and CL extracts were inspected using HPLC-DAD to explore the bioactive phytochemical compounds.
Acute toxicity test showed that LD50 was 1500 and 2333 mg/kg b.wt. for CL and CF, respectively. The cytogenetic study
was also done to detect the chromosome aberrations in somatic and germ cells after CL and CF administration to mice.
DPPH antioxidant capacity assay revealed that CL has high redox-active effect than CF. This study is a contribution to the
development of a creative new DDS that help in cancer treatment.
 
Date 2021-07-28T05:10:55Z
2021-07-28T05:10:55Z
2021-06
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscair.res.in/handle/123456789/57761
 
Language en
 
Relation Int. cl. (2015.01)- A61K 36/00, A61K 36/74, A61K 127/00, A61K 133/00, A61P 35/00
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.12(2) [June 2021]